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|File Description||Dialog File Data||DIALINDEX/OneSearch Categories||Basic Index||Rank|
|Subject Coverage||Document Types Indexed||Contact||Additional Indexes||Predefined Format Options|
|Tips||Geographic Coverage||Terms and Conditions||Limit||Rates|
|Print Counterparts||Special Features||Sample Record||Sort|
ExtraMEDTM presents a unique perspective on the much-neglected biomedical literature of the developing countries. Use File 467 to make a quick check of alternative literature, which may contain unexpected and often unique information. ExtraMED was developed to serve as an important new global research and diagnostic tool.
ExtraMED was created in 1993 on the initiative of the World Health Organization (WHO), which brought together the publishers of over 290 biomedical journals from all over the world into the ExtraMED Consortium. Most of the articles found in File 467 are not included in major European and U.S. indexing sources, making ExtraMED a particulary valuable source of information.
The file provides all the abstracts and bibliographic data from the WHO initiative. Articles provide a unique perspective on all health and biomedical topics. The full-text articles are available individually from DIALOG SourceOneSM document delivery service.
USE FILE 467
to locate unique biomedical articles (not covered in other biomedical databases) from developing countries.
USE SELECT JN=
to see a complete list of journal names included in the database.
USE LIMITS/ABS for records with abstracts.
USE RANK AU
to locate experts in a specific discipline./p>
Information reported in ExtraMED includes:
|Dates Covered:||1992 to 2000|
|File Size:||16,609 records|
|PHARMR||Pharmacology + RINGDOC-Files|
ExtraMED is provided by Informania Limited. Questions concerning the content of the file should be directed to:
P.O. Box 40
Petersfield, Hants, GU32 2YH
For Dialog's Redistribution and Archive Policy, enter HELP ERA online.
Database (c)1997 Informania Ltd, All rights reserved.
|(c) 1996 Informania Ltd. All rts. reserv.|
|/TI||Induction of Erythroid Differentiation of Human|
|Erythroleukemia K-562 Cells by Mutactimycin|
|AU=||Wu Q; Li D-D; Zhen Y-S|
|JN=, PY=||Journal of Chinese Pharmaceutical Sciences. 1995, Vol. 4,|
|No. 2, p. 82-88 (7 pages)|
|LANGUAGE: English ISSN: 1003-1057|
|/AB||Mutactimycin, a new anthracycline antibiotic, consists of|
|5 components: mutactimycin A, B, C, D and|
|7-deoxymutactimycinone A. Mutactimycin components differ|
|from each other in suppressing proliferation and inducing|
|differentiation of human erythro-leukemia K-5 62 cells.|
|Determined by benzidine staining, the percentage of K-562|
|cells with hemoglobin expression was 86% by mutactimycin C.|
|The peak percentage of benzidine positive cells appeared on|
|day 5 or 6. The differentiated cells were partially reversed|
|after drug removal. The induced cells lost the clonogenicity|
|in soft-agar. The kinetics of differentiation induced by|
|mutactimycin C, in comparison with other known anthracycline|
|antibiotics, was similar to that by doxorubicin, epirubicin|
|and daunorubicin. Mutactimycin C was more active than|
|aclarubicsin A. The structure- activity relationship for|
|mutactimycin components suggested that the substituting|
|groups on C3, C11, and the saccharide on C7 might be|
|important for their activities.|
|/DE||DESCRIPTORS: Differentiation; K-562 cells; Mutactimycin;|
|None||None||All Basic Index Fields||Word||S HUMAN(W)ERYTHROLEUKEMIA|
S STRUCTURE-ACTIVITY RELATIONSHIP/DE
1 Not present in all records.
|AU=||AU||Author||Phrase||S AU=ZHEN Y-S|
|None||AZ||DIALOG Accession Number|
|JN=||JN||Journal Name||Phrase||S JN=JOURNAL OF CHINESE PHARMACEUTICAL?|
|PY=||PY||Publication Year||Phrase||S PY=1995|
2 Display includes Journal Name, Publication Year, Volume, Issue, and Pagination.
|/ABS||Abstract Present||S S2/ABS|
|AU, JN, PY, TI||SORT S6/ALL/TI|
|All phrase- and numeric-indexed fields in the Additional Indexes can be ranked.||RANK JN|
RANK DE S4
|Display codes listed in the Search Options tables can be used to customize output.||TYPE S4/TI,JN/1-5. PRINT S5/TI,JN/ALL|
|1||--||DIALOG Accession Number|
|2||--||Full Record less abstract1|
|4||--||Full Record with Tagged Fields1|
|6||Short||Title and Publication Year|
|7||Long||Full record less indexing1|
|8||Free||Title and Indexing1|
|K||--||KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats|
|If the accession number of a specific record is known, it can be used to display the record directly.||TYPE 00009234/9
Rates For File: ExtraMED™ Cost per DialUnit: $9.00 Cost per minute: $2.02 Rank Elements $0.00 Format Types Prints 1 $0.00 $0.00 2 $2.00 $2.00 3 $2.00 $2.00 4 $5.00 $5.00 5 $5.00 $5.00 6 $0.00 $0.00 7 $5.00 $5.00 8 $0.00 $0.00 9 $5.00 $5.00 KWIC95 $0.33 NA KWIC96 $0.33 NA REDIST/COPY Multiplier Table: Range Multiplier 1-2 1.00 3-25 1.50 26-100 3.00 101-200 4.00 201-500 6.00 501-1000 8.00 1001 or more 10.00 ARCHIVE Multiplier Table: Range Multiplier 1-25 1.50 26-200 3.00 201-500 6.00 501-1000 8.00 1001 or more 10.00