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File Description [top]

Prous Science Daily Essentials^TM, produced by Prous Science Publishers, is a clear, concise and flexible database that provides up-to-date drug R&D information. More than 25 late-breaking news items including information from ongoing congresses and conferences are posted in the current file (File 458) each business day. It offers users practical and accurate information including chemical structures, data tables and other images for day-to-day decisions in drug R&D and marketing. A searchable archive (File 459) gives access to more than 25,000 news items dating back to early 1996. These files are a valuable source of up-to-date information for professionals in research, development, management, marketing, licensing, and new business development within the pharmaceutical industry and for all those interested in this industry's activities.

Tips [top]

Subject Coverage [top]

Prous Science Daily Essentials database provides the following information:

• Title
• Drug Name
• Company Name
• Therapeutic Classification
• Patent Numbers (where available)
• Development Status
• Text

Sources [top]

Principal sources for the news items published in Prous Science Daily Essentials are the current biomedical literature, patent literature, congresses, company communications, and Internet monitoring. The most recent patent literature is from 11 different sources, reflecting research activity throughout the world. The database includes the information from 1,500 journals, 300 congresses and meetings, company communications and Internet Monitoring. The information describes the activity of more than 2,500 companies, research institutes and universities.

Dialog File Data [top]

Database Content [top]

• Complete-text Records with Image

Document Types Indexed [top]

• Complete Text

Geographic Coverage [top]

• International

Special Features [top]

• ERA Available
• KWIC and HILIGHT Available
• DIALOG Alert Available
• Image Output Available

DialIndex/OneSearch Categories [top]

Contact [top]

Terms and Conditions [top]

For Dialog's Redistribution and Archive Policy, enter HELP ERA online. The following terms and conditions also apply. (c)2000 Prous Science, S.A. All rights reserved. No part of this electronic database may be reproduced, abstracted, or transmitted in any form or by any means --electronic, mechanical, photocopying, recording, or otherwise--without the express written permission of the publisher, Prous Science, S.A. While great care has been taken in the preparation of this database, and the publisher has made a reasonable effort to supply complete and accurate information, it does not assume any liability for errors or omissions. Prous Science, S.A. makes no warranties, expressed or implied, with respect to the accuracy, quality, validity, or completeness of this database or the information therein or its merchantability or fitness for a particular purpose.

SAMPLE RECORD [top]

	DIALOG(R)File 458:Daily Essentials
	(c) 2000 Prouse Science. All rts. reserv.
	00032686
/TI	ERYLOSIN F: A NEW THROMBIN RECEPTOR ANTAGONIST PRODUCED BY A MARINE SPONGE
JN=	Daily Essentials
PD=,PY=	May 17, 2000 (20000517)
DT=	DOCUMENT TYPE: Current Literature
/ST,ST=	DEVELOPMENT STATUS: New Compound
LA=	LANGUAGE: English
RT=	RECORD TYPE: Fulltext; Image
/TX	A novel penasterol disaccharide designated eryloside F has been
	discovered during a screening for thrombin receptor antagonists at Glaxo
	Wellcome and the Harbor Branch Oceanographic Institution. Isolated from an
	extract of the marine sponge Erylus formosus, the compound is closely
	related to formoside and acts as a potent and relatively selective thrombin
	receptor antagonist and antiplatelet agent, as demonstrated by IC50 values
	for inhibition of SFLLRN (thrombin receptor-activating peptide)- and
	U-46619-induced human platelet aggregation of 0.3 mcg/ml and 1.7 mcg/ml,
	respectively. It is also reported to possess low toxicity in HepG2 cells
	(Stead, P. et al. Bioorg Med Chem Lett 2000, 10(7): 661).
/CO,CO=	NAMED COMPANIES: Glaxo Wellcome; Harbor Branch Oceanographic Institution
/NA,NA=,/SY,SY=,AA=	NAMED DRUGS: Eryloside F [288492]
/TC,TC=	THERAPEUTIC CLASS: Blood Coagulation, Agents Affecting; Antiplatelet
	Therapy

BASIC INDEX [top]

¹ Searchable in the Basic Index and in the Additional Indexes.

² Also searchable using /DE, /DF.

ADDITIONAL INDEXES [top]

³ This field will appear in a record only if a drug name is present in the record. This number is not unique as record may discuss multiple drugs each with their own AA.

⁴ All records are in English.

⁵ All records are full-text.

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Rates [top]

Rates For File: Prous Science Daily Essentials - Daily[458]
Cost per DialUnit:                 $9.18
Cost per minute:                   $3.70
Rank Elements                      $0.00

Format    Types   Prints
     1    $0.00    $0.00
     2    $7.00    $7.00
     3    $4.00    $4.00
     4   $13.00   $13.00
     5   $13.00   $13.00
     6    $0.00    $0.00
     7   $13.00   $13.00
     8    $7.00    $7.00
     9   $13.00   $13.00
    19   $15.00   $15.00
KWIC95    $4.00       NA
KWIC96    $4.00       NA

REDIST/COPY Multiplier Table:

      Range      Multiplier
        1-2       1.00
       3-25       1.50
     26-100       3.00
    101-200       4.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

ARCHIVE Multiplier Table:

      Range      Multiplier
       1-25       1.50
     26-200       3.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

Rates For File: Prous Science Daily Essentials - Weekly[459]
Cost per DialUnit:                 $9.18
Cost per minute:                   $3.70
Rank Elements                      $0.00

Format    Types   Prints
     1    $0.00    $0.00
     2    $7.00    $7.00
     3    $4.00    $4.00
     4   $13.00   $13.00
     5   $13.00   $13.00
     6    $0.00    $0.00
     7   $13.00   $13.00
     8    $7.00    $7.00
     9   $13.00   $13.00
    19   $15.00   $15.00
KWIC95    $4.00       NA
KWIC96    $4.00       NA

REDIST/COPY Multiplier Table:

      Range      Multiplier
        1-2       1.00
       3-25       1.50
     26-100       3.00
    101-200       4.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

ARCHIVE Multiplier Table:

      Range      Multiplier
       1-25       1.50
     26-200       3.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00