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Last Loaded on Web: Monday, April 01, 2013
The Prous Science Drug Data Report database provides continuously updated information on more than 65,000 bioactive compounds reported in the print journal Prous Science Drug Data Report since June 1988. Compounds are "followed" from the patent application stage through research and development phases to approval, marketing, and postmarketing periods. Approximately 10,000 records were added to the database each year. The Prous Science Drug Data Report database is a valuable source of up-to-date information for professionals in research, development, management, marketing, licensing, and information sciences within the pharmaceutical industry and for all those interested in this industry activities.
USE FILE 452to monitor drugs in the pipeline from preclinical, clinical (phase I, phase II, or phase III) as well as launch, registered, etc., all indexed by development status (ST=). USE THERAPEUTIC CODESto choose therapeutic class EXPAND TC=10000or SELECT ANTICONVULSANT/TC USE FORMAT 13to display full record except text & literature references with image. USE FORMAT 19to display full record with image(s). /p> |
Fields in the Prous Science Drug Data Report database include:
The entries in the Prous Science Drug Data Report database are included from information compiled from published and unpublished sources: current literature references (as of June 1, 1995, more than 100,000 are included in the database); patent references (more than 20,000) from 11 different sources; international congresses and symposia (more than 160 anually); scientific contributions; and company communications (from more than 850 companies).
| Dates Covered: | June 1, 1988 to February 2011 |
|---|---|
| File Size: | 222,239 records |
| Update Frequency: | Closed (Approximately 1,000 records) |
For addditional information about Chemical Structure searching available in this file, please see CSS
| ACRONYM | CATEGORY NAME |
|---|---|
| BRANDNMS | Brand Names |
| CASREGNO | CAS(R) Registry Numbers-Chemical and Medical Files |
| CHEMSTRC | Chemical Structure Search |
| DRUGDEV | Drug Development Pipeline |
| DRUGDIR | Drug Directories |
| PHARM | Pharmacology |
| PHARMR | Pharmacology + RINGDOC-Files |
| PROUS | Prous Science Publishers Files |
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Prous Science Drug Data Report is provided by Prous Science Publishers. Questions concerning file content should be directed to: P.O. Box 540 Barcelona, 08080 Spain
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For Dialog's Redistribution and Archive Policy, enter HELP ERA online. The following terms and conditions also apply. (c)2000 J.R. Prous, S.A. All rights reserved. No part of this electronic database may be reproduced, abstracted, or transmitted in any form or by any means--electronic, mechanical, photocopying, recording, or otherwise--without the express written permission of the publisher, J.R. Prous, S.A. While great care has been taken in the preparation of this database, and the publisher has made a reasonable effort to supply complete and accurate information, it does not assume any liability for errors or omissions. J.R. Prous, S.A. makes no warranties, expressed or implied, with respect to the accuracy, quality, validity, or completeness of this database or the information therein or its merchantability or fitness for a particular purpose.
| DIALOG(R)File 452:Prous Science Drug Data Report | |
| (c) 2000 J.R. Prous S.A. All rts. reserv. | |
| 00149658 | |
| AA= | ENTRY NUMBER: 149658 |
| COMPOUND TYPE: Preferred | |
| /SY, SY=,/NA,NA= | DRUG NAME: 256U87 |
| BW-256U | |
| ValACV | |
| /NA,NA= | GENERIC NAME Valaciclovir (recommended INN) |
| Valacyclovir (USAN) | |
| /TN,TN= | BRAND NAME: Valtrex (Wellcome, GB, EI) |
| /CN,CN= | CHEM NAME: L-Valine 2-(2-amino-6-hydroxy-9H-purin-9- |
| ylmethoxy) ethyl ester | |
| L-Valine 2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9- | |
| ylmethoxy)ethyl ester | |
| L-Valine 2-(guanin-9-ylmethoxy)ethyl ester | |
| MF= | FORMULA: C13H20N6O4 |
| RN= | CAS REG. NO.: 124832-26-4 |
| 124832-27-5 (monoHCl salt) | |
| ST= | DEVEL. PHASE: Launched (1995) |
| /LO, LO= | ORIGINATOR: Wellcome |
| /LI, LI= | LICENSEE: Hoechst |
| Theraplix | |
| RE= | RELATED ENTRY: 151566 (secondary) |
| /TX | ACTION: Antiviral agent, ester of the antiherpetic |
| compound acyclovir, with better water solubility and | |
| gastrointestinal absorption after oral administration than | |
| acyclovir, without substantial decline of the antiviral activity | |
| in vitro. In rats, urinary recovery as acyclovir was 63 % of the | |
| dose for the title compound and 15 % for acyclovir. Another | |
| specifically claimed amino acid ester of the known purine | |
| nucleoside is: 151566. (Drug Data Report, Vol. 11, No. 7, p. 592, | |
| 1989) | |
| ACTION: Acyclovir prodrug, ester with L-valine that was | |
| found to berapidly converted to the parent compound in studies in | |
| rats and primates; due to good results in these studies, it was | |
| advanced to clinical testing in man. In single-dose studies in | |
| healthy volunteers , it gave peak acyclovir values of 0.8 +/- 0.1 | |
| and 5.6 +/- 2.4 mcg/ml at 24 h after administration of 100 or | |
| 1000 mg, respectively. Mean t1/2 at all doses was approx. 28 h. | |
| After multiple doses in volunteers (250,500 or 1000 mg four times | |
| daily for 11 days), pharmacokinetic parameters were similar to | |
| those after single dosing. Due to the compound'senhanced delivery | |
| of acyclovir and its favorable pharmacokinetic profile, it has | |
| been moved to phase II studies. (Drug Data Report, Vol. 13, No. | |
| 11, p. 998, 1991) | |
| PREV. PUB. IN: Drugs of the Future, Vol. 18, No. 7, p. 619, 1993 | |
| PATENTS: | |
| /TI | THERAPEUTIC NUCLEOSIDES |
| AU= | AUTHOR(s): Beauchamp, L.M., Krenitsky, T.A. |
| PA= | APPLICANT(s): Wellcome Found. |
| PC=, PN= | FAMILY: 20978 [AU 8820978 Austria, February 16, |
| 1989 | |
| 308065 [EP 308065 European Patent Office, | |
| March 22, 1989 | |
| 596542 [EP 596542 European Patent Office, | |
| May 11, 1994 | |
| 1-068373 [JP 1068373 Japan, March 14, 1989 | |
| 3-115284 [JP 3115284 Japan, May 16, 1991 | |
| 4,957,924 [US 4957924 United States of America, | |
| September 18, 1990 | |
| 5,061,708 [US 5061708 United States of America, | |
| October 29, 1991 | |
| AN= | PRIORITY: 8719367 [GB 8719367 Great Britain, August 15, |
| 1987 | |
| 8725939 [GB 8725939 Great Britain, November | |
| 5, 1987 | |
| /RF, RF= | REFERENCES: |
| Blum, M.R. et al., "Single and multiple-dose pharmacokinetics of | |
| a new acyclovir prodrug, 256U87, in healthy volunteers", 31st | |
| Intersci Conf Antimicrob Agents Chemother (Sept 29-Oct 2, | |
| Chicago) 1991, Abst 763 | |
| De Miranda, P. and Burnette, T.C., "Metabolism and | |
| pharmacokinetics of the acyclovir prodrug BW 256U87 in cynomolgus | |
| monkeys", Antivir Res 1992, 17(Suppl. 1): Abst 19 | |
| Burnette, T.C. and De Miranda, P., "Metabolic disposition of BW | |
| 256U87, the L-valyl ester of acyclovir, in the rat", Antivir Res | |
| 1992, 17(Suppl. 1): Abst 142 | |
| Beauchamp, L. et al., "Amino acid esters of acyclovir as oral | |
| prodrugs", Antivir Res 1992, 17(Suppl. 1): Abst 143 | |
| (...) | |
| "Valtrex - Wellcome's successor to Zovirax - approved", Wellcome | |
| plc News Release 1995, January 27 | |
| Wellcome plc Annual Report 1994 |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields | Word | S ANTIVIRAL |
| /CN | CN | Chemical Name2 | Word | S VALINE(W)2/CN |
| /CO | CO | Company Name1,2 | Word | S WELLCOME/CO |
| /LI | LI | Licensee2 | Word | S THERAPLIX/LI |
| /LO | LO | Originator2 | Word | S WELLCOME/LO |
| /NA | NA | Chemical Name2,3 | Word | S VALACV/NA |
| /RF | RF | Cited References2 | Word | S ACYCLOVIR/RF |
| /SY | SY | Drug Name2,4 | Word | S VALACYCLOVIR/SY |
| /TC | TC | Therapeutic Class Text5 | Word | S ANTIVIRAL/TC |
| /TI | PI | Patent Title | Word | S NUCLEOSIDES/TI |
| /TN | TN | Brand Name2 | Word | S VALTREX/TN |
| /TX | TX | Text | Word | S PURINE(W)NUCLEOSIDE/TX |
1 Includes Licensee (/LI, LI=) and Originator (/LO, LO=).
2 Searchable in the Basic Index and in the Additional Indexes.
3 Includes Chemical Name, Laboratory Code, Brand Name, and Generic Drug Name.
4 Includes Laboratory Code,Brand Name, and Generic Drug Name.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| AA= | AA | Prous Entry Number | Phrase | S AA=149658 |
| AC= | AC | Application Country | Phrase | S AC=GB |
| AN= | PI | Patent Application/Priority Number | Phrase | S AN=GB 8719367 |
| AU= | PI | Patent Inventor Name | Phrase | S AU=BEAUCHAMP L? |
| None | AZ | DIALOG Accession Number | ||
| CN= | CN | Chemical Name2 | Phrase | S CN=L-VALINE 2? |
| CO= | CO | Company Name1,2 | Phrase | S CO=WELLCOME? |
| FS= | FS | File Segment | Phrase | S FS=ACTIVELY INVESTIGATED |
| None | IM | Image | ||
| LI= | LI | Licensee2 | Phrase | S LI=THERAPLIX |
| LO= | LO | Originator2 | Phrase | S LO=WELLCOME |
| MF= | MF | Molecular Formula | Phrase | S MF=C13H20N6O4 |
| NA= | NA | Chemical Name2,3 | Phrase | S NA=VALACV |
| PA= | PI | Patent Applicant/Assignee | Word & Phrase |
S PA=(WELLCOME(W)FOUND?) S PA=WELLCOME? S PA=WELLCOME? |
| None | PC | Preferred Compound | ||
| PC= | PI | Patent Country | Phrase | S PC=JP |
| PN= | PI | Patent Number | Phrase | S PN=EP 308065 |
| None | PP | Properties | ||
| None | PU | Previously Published In | ||
| RE= | RE | Related Entry Number | Phrase | S RE=151566 |
| RF= | RF | Cited References2 | Word | S RF=(BURNETTE(W)T(W)C) |
| RN= | RN | CAS(R) Registry Number | Phrase | S RN=124832-26-4 |
| RT= | None | Record Type | Phrase | S S1 AND RT=IMAGE |
| ST= | ST | Development Status | Phrase | S ST=PREREGISTERED |
| SY= | SY | Drug Name2,4 | Phrase | S SY=VALACYCLOVIR |
| TC= | TC | Therapeutic Class Code/Class Name | Phrase | S TC=71000 |
| TN= | TN | Brand Name2 | Phrase | S TN=VALTREX |
| UC= | None | Update-changed records | Phrase | S UC=9999 |
| UD= | None | Update | Phrase | S UD=9999 |
| SUFFIX | FIELD NAME | EXAMPLES |
|---|---|---|
| /PREF | Compound Type -- Preferred | S S2/PREF |
| /SEC | Compound Type -- Secondary | S S2/SEC |
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| CO, LO, NA, RN, ST, SY | SORT S1/ALL/LO,D PRINT S5/5/1-24/LO |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. | RANK LO RANK LI S4 |
| MAP FIELDS | EXAMPLES |
|---|---|
| AN, NA, PN, PREF, PREFSEC, RN, SEC | MAP ANYY TEMP S2 MAP RN TEMP S1 |
| Display codes listed in the Search Options tables can be used to customize output. | TYPE S3/CO, NA/1-5 PRINT S2/AN, RN/ALL |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Full Record except patents and literature references |
| 3 | Short | Full Record except text, patents and literature references |
| 4 | -- | Full Record with Tagged Fields |
| 5 | Medium | Full Record except literature references |
| 6 | -- | Entry Number, Compound Type and Therapeutic Class |
| 7 | -- | Full Record except literature references |
| 8 | Free | Entry Number, Compound Type and Therapeutic Class |
| 9 | Long | Full Record |
| 12 | -- | Full Record except patents and literature references with image. |
| 13 | -- | Full Record except text, patents and literature references with image. |
| 14 | -- | Full Record--tagged format with image |
| 15 | -- | Full Record except literature references with image |
| 16 | -- | Entry Number, Compound Type and Therapeutic Class with image |
| 17 | -- | Full Record except literature references with image |
| 18 | -- | Entry Number, Compound Type and Therapeutic Class with image |
| 19 | Full | Full Record with image(s) |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| If the accession number of a specific record is known, it can be used to display the record directly. | TYPE 00149658/5 DISPLAY 00149658/AA,NA PRINT 00149658/9 |
||
Rates For File: Prous Science Drug Data Report[452]
Cost per DialUnit: $12.39
Cost per minute: $3.52
Rank Elements $0.00
Format Types Prints
1 $0.00 $0.00
2 $17.00 $17.00
3 $10.00 $10.00
4 $28.00 $28.00
5 $20.00 $20.00
6 $0.00 $0.00
7 $20.00 $20.00
8 $0.00 $0.00
9 $28.00 $28.00
12 $20.00 $20.00
13 $13.00 $13.00
14 $30.00 $30.00
15 $25.00 $25.00
16 $3.50 $3.50
17 $25.00 $25.00
18 $3.50 $3.50
19 $30.00 $30.00
KWIC95 $2.75 NA
KWIC96 $2.75 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
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