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Last Loaded on Web: Wednesday, May 01, 2013
The Derwent Drug File, produced by Thomson Reuters is a complete information package, specifically designed to meet the information requirements of the pharmaceutical industry. It provides references from the worldwide pharmaceutical literature going back to 1964. The database covers all aspects of drug synthesis, development, evaluation, manufacture, and use. The highly focused coverage of the database ensures that all information retrieved from it is strongly drug-oriented. In addition, the unique combination of biological and chemical information enables searchers to find data on all types of structure-activity relationships.
The Derwent Drug File contains two file pairs of publicly accessible and companion subscriber-only files. Files 377/912 contain records from 1983 to the present; Files 376/913 contain records from 1964-1982 and are closed files that are no longer updated. Each record in the database contains extremely detailed, controlled-language indexing, together with bibliographic information. An English-language summary abstract of approximately 100 words is present in all records in Files 377/912. The subscriber-only file (File 912) contains a more detailed Extension Abstract of up to 250 words.
Derwent Drug File provides detailed coverage of all aspects of drugs. The data includes the preparation and testing of potential drugs, analysis, pharmaceutics, pharmacology, therapy, adverse effects and toxicology, pharmacokinetics, isolation from natural sources, biochemistry, immunology, etc.
More than 1,150 worldwide key journals, chosen in consultation with a committee of user representatives to give comprehensive coverage, are regularly and promptly scrutinized for relevant papers.
| ACRONYM | CATEGORY NAME |
|---|---|
| CASREGNO | CAS(R) Registry Numbers-Chemical and Medical Files |
| PHARM | Pharmacology |
| PHARMR | Pharmacology + RINGDOC-Files |
| RNMED | CAS(R) Registry Numbers - Medical Files |
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The Derwent Drug File is produced by Thomson Scientific. Questions about file content should be submitted by Web Form at www.thomsonscientific.com/support/techsupport or directed to: 14 Great Queen Street London, WC2B 5DF England
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Palaceside Bldg. 5F 1-1-1 Hitotsubashi, Chiyoda-ku Tokyo 100-0003, Japan
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Six Battery Road #29-03 Singapore 049909,
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Database(s) copyrighted by The Thomson Corporation.
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| DIALOG(R) File 377:Derwent Drug File | |
| (c) 2010 Thomson Reuters. All rights reserved. | |
| AA= | 00145460 DERWENT ACCESSION NUMBER: 94-12001 |
| /TI | New Compounds Related to Pdodpyllotoxim and Congeners: Synthesis, |
| Structure Elucidation and Biological Testing | |
| AU= | Hansen H F; Jensen R B; Willumsen AM; Norskov Lauritsen N; Ebbesen |
| P; Nielsen PE | |
| CS= | Univ. Copenhagen (Copenhagen; Aarhus, Den.) |
| JN=, PY= | Acta Chem.Scand., v47, n12, p1190-200, 1993 |
| CD=, SN=, LA=, | CODEN: ACHSE7 ISSN: 0904-213X LANGUAGE: English RECORD TYPE: |
| RT= | Abstract |
| REPRINT ADDRESS: LP Research Center for Medical Biotechnology, | |
| Chemical Laboratory II, The H.C. Orsted Institute, University | |
| of Copenhagen, DK-2100 Copenhagen, Denmark. | |
| (Buchardt O, 7 authors). | |
| ABSTRACT: | |
| /AB | 4-Azido, 4-amino, 4-amido and 4-alkoxy compounds related to the |
| lignans podophyllotoxin (podofilox) and 4'-demethyl | |
| epipodophyllotoxin were prepared and evaluated for cytotoxic | |
| activity. All compounds inhibited the growth of human cervical | |
| cancer cells and TC-mouse cells with 4-amino-4-deoxy | |
| podophyllotoxin and 4-azido-4-deoxy podophyllotoxin showing the | |
| greatest activity. Alkaline elution studies showed that toxicity of | |
| 4'-demethoxy derivatives was due to protein-mediated DNA nicking. | |
| None of the compounds showed antiviral activity against HSV-2 in MS | |
| 751 cells, HIV in CEM cells of cytomegalovirus (CMV) in human | |
| embryo | |
| fibroblasts MRC-5 at non-toxic doses. | |
| SF= | SPECIAL FEATURES: 1 Fig. 1 Tab. 25 Ref. |
| LINK TERMS: | |
| /DE | *01*; 027 --PI; 026 --PI; 310 --PI; 314 --PI; PODOFILOX --RC; |
| PICROPODOPHYLLOTOXIN --RC; DEMETHYLPODOPHYLLOTOXIN-4+ --RC; | |
| NEW --FT; IN-VITRO --FT; CYTOSTATIC --FT; VIRUCIDE --FT; | |
| HERPES-SIMPLEX-VIRUS --FT; CYTOMEGALO-VIRUS --FT; TC-CELL --FT; | |
| MS751-CELL --FT; TUMOR-CELL --FT; CEM-CELL --FT; FIBROBLAST --FT; | |
| NAPHTHALENE --FT; COND.RING--FT; DIOXOLE --FT; ISOBENZOFURAN --FT; | |
| LACTONE --FT; BA-LINKED --FT; BIPHENYL --FT; POLYPHENOL --FT; | |
| PHENOL-ETHER--FT; ALKYLBROMIDE--FT; ALKYLCHLORIDE--FT; AZIDE --FT; | |
| ALCOHOL --FT; AMINE --FT; OLEFIN --FT; ARYL-C-AMIDE --FT; | |
| ACRIDINE --FT; ETHER --FT; LEUKOVIRUS --FT; HERPESVIRUS --FT; | |
| VIRUS --FT; TISSUE-CULTURE --FT; OC --FT; 02& --G; 021 --G; | |
| 022 --G; 023 --G; 03& --G; 030 --G; 031 --G; 033 --G; 034 --G; | |
| 044 --G; 05& --G; 063 --G; 066 --G; 071 --G; 08& --G; 080 --G; | |
| 09& --G; 099 --G; 10- --G; 101 --G; 102 --G; 11- --G; 110 --G; | |
| 116 --G; 12& --G; 123 --G; 13& --G; 131 --G; 134 --G; 14- --G; | |
| 151 --G; 172 --G; 18& --G; 180 --G; 181 --G; 182 --G; 183 --G; | |
| 184 --G; 19- --G; 190 --G; 192 --G; 199 --G; 235 --G; 237 --G; | |
| 25- --G; 250 --G; 254 --G; 257 --G; 259 --G; 26& --G; 26- --G | |
| /SH, SH=, SC= | SECTION HEADINGS: Structure/Activity (38); Virucides (41); |
| Chemotherapy --hnon-clinical (52); Medicinal Chemistry (71) | |
| TG= | THEMATIC GROUPS: C (Chemistry); P (Pharmacology); M (Microbiology) |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields1 | Word | S STRUCTURE(W)ELUCIDATION |
| /AB | AB | Abstract, Extension Abstract2,3 | Word | S HIV/AB |
| /DE | DE | Common Terms, Link Terms4 | Word & Phrase |
S PODOFILOX(W)RC/DE S VIRUS/DF |
| /NA | NA | Derwent Drug Registry Name2 | Word | S AMPHETAMI/NA |
| /SH | SH | Section Heading5 | Word | S STRUCTURE(W)ACTIVITY/SH |
| /TI | TI | Title | Word | S STRUCTURE(W)ELUCIDATION/TI |
1 Chemical names can be searched as chemical segmented terms or as complete words. Use /FW to restrict retrieval to the complete term, e.g., S METHANE/FW.
3 Extension Abstracts in File 912 only.
5 Searchable in the Basic Index and in the Additional Indexes.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| AA= | AA | Derwent Accession Number | Phrase | S AA=94-12001 |
| None | AD | Reprint Address | ||
| None | AN | DIALOG Accession Number | ||
| AU= | AU | Author | Phrase | S AU=JENSEN R B |
| CD= | CD | CODEN | Phrase | S CD=ACHSE7 |
| CS= | CS | Corporate Source | Word & Phrase |
S CS=(UNIV?(W)COPENHAGEN) S CS=UNIV.COPENHAGEN |
| JN= | JN | Journal Name | Phrase | S JN=ACTA CHEM.SCAND. |
| LA= | LA | Language2 | Phrase | S LA=ENGLISH |
| NA= | NA | Derwent Drug Registry Name2 | Phrase | S NA=AMPHETAMI |
| PY= | PY | Publication Year | Phrase | S PY=1993 |
| RN= | RN | CAS(R) Registry Number2 | Phrase | S RN=300-62-9 |
| RT= | RT | Record Type | Phrase | S RT=ABSTRACT |
| SC= | SC | Section Heading Code | Phrase | S SC=38 |
| SF= | SF | Special Feature2 | Word | S SF=REF |
| SH= | SH | Section Heading | Phrase | S SH=VIRUCIDES |
| SN= | SN | International Standard Serial Number (ISSN)2 | Phrase | S SN=0904-213X |
| None | SO | Source Information6 | ||
| TG= | TG | Thematic Group | Phrase | S TG=C S TG=CHEMISTRY |
| UD= | None | Update | Phrase | S UD=9999 |
6 Display includes journal name, volume, issue, page number, and publication year.
| SUFFIX | FIELD NAME | EXAMPLES |
|---|---|---|
| / | DIALOG Accession Number | S S3/597914-999999 |
| /ENG | English-Language Articles | S UD=9999/ENG |
| /NONENG | Non-English-language Articles | S S1/NONENG |
| /YYYY | Publication Year | S INFLUENZA(F)ELDERLY/TI,2010 |
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| AU, JN, PY, TI | SORT S13/ALL/AU PRINT S5/1-24/TI |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: DE | RANK DE RANK AU S4 |
| MAP FIELDS | EXAMPLES |
|---|---|
| NA, RN | MAP RN TEMP S2 |
| Display codes listed in the Search Options tables can be used to customize output. | TYPE S3/TI,AB/1-5 |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Bibliographic Citation and Indexing |
| 3 | Medium | Bibliographic Citation |
| 4 | -- | Full Record with Tagged Fields2,3 |
| 5 | -- | Full Record2,3 |
| 6 | Free | Title and Derwent Accession Number |
| 7 | Long | Full Record except Indexing2,3 |
| 8 | Short | Title and Indexing |
| 9 | Full | Full Record2,3 |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| If the accession number of a specific record is known, it can be used to display the record directly. | TYPE 62331/5 DISPLAY 62331/TI,LP PRINT 618279/9 |
||
Rates For File: Derwent Drug File (1964-1982)[376]
Standard Subscrib
Cost per DialUnit: $19.50 $21.45
Cost per Minute: $3.08 $3.40
Rank Elements $0.06 $0.07
<< Standard >> << Subscriber >>
Format Types Prints Types Prints
1 $0.00 $2.28 $0.00 $2.50
2 $2.28 $2.28 $2.50 $2.50
3 $2.28 $2.28 $2.50 $2.50
4 $2.28 $2.28 $2.50 $2.50
5 $2.28 $2.28 $2.50 $2.50
6 $0.00 $2.28 $0.00 $2.50
7 $2.28 $2.28 $2.50 $2.50
8 $0.00 $2.28 $0.00 $2.50
9 $2.28 $2.28 $2.50 $2.50
66 $2.14 $2.14 $2.36 $2.36
KWIC95 $0.22 NA $0.24 NA
KWIC96 $0.22 NA $0.24 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
Rates For File: Derwent Drug File (1983-present)[377]
Standard Subscrib
Cost per DialUnit: $19.50 $21.45
Cost per Minute: $3.08 $3.40
Rank Elements $0.06 $0.07
ALERT (default) $19.80 $21.80
ALERT (Monthly) $48.50 $53.35
ALERT (Biweekly/twice a month) * $32.40 $35.60
ALERT (Weekly) $19.80 $21.80
ALERT (Daily) * $19.80 $21.80
ALERT (Calendar weekly) * $19.80 $21.80
ALERT (Intraday) * $19.80 $21.80
* = custom scheduled Alerts only
<< Standard >> << Subscriber >>
Format Types Prints Types Prints
1 $0.00 $2.28 $0.00 $2.50
2 $2.28 $2.28 $2.50 $2.50
3 $2.28 $2.28 $2.50 $2.50
4 $3.46 $3.46 $3.80 $3.80
5 $3.46 $3.46 $3.80 $3.80
6 $0.00 $2.28 $0.00 $2.50
7 $3.46 $3.46 $3.80 $3.80
8 $0.00 $2.28 $0.00 $2.50
9 $3.46 $3.46 $3.80 $3.80
66 $3.30 $3.30 $3.64 $3.64
KWIC95 $0.22 NA $0.25 NA
KWIC96 $0.22 NA $0.25 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
Rates For File: Derwent Drug File (1983-present) - subscribers[912]
Standard Subscrib
Cost per DialUnit: $11.50 $12.65
Cost per Minute: $2.33 $2.57
Rank Elements $0.06 $0.07
ALERT (default) $14.40 $15.85
ALERT (Monthly) $30.60 $33.70
ALERT (Biweekly/twice a month) * $21.75 $23.90
ALERT (Weekly) $14.40 $15.85
ALERT (Daily) * $14.40 $15.85
ALERT (Calendar weekly) * $14.40 $15.85
ALERT (Intraday) * $14.40 $15.85
* = custom scheduled Alerts only
<< Standard >> << Subscriber >>
Format Types Prints Types Prints
1 $0.00 $1.34 $0.00 $1.47
2 $1.34 $1.34 $1.47 $1.47
3 $1.34 $1.34 $1.47 $1.47
4 $1.43 $1.43 $1.57 $1.57
5 $1.43 $1.43 $1.57 $1.57
6 $0.00 $1.34 $0.00 $1.47
7 $1.43 $1.43 $1.57 $1.57
8 $0.00 $1.34 $0.00 $1.47
9 $1.43 $1.43 $1.57 $1.57
66 $1.30 $1.30 $1.43 $1.43
KWIC95 $0.13 NA $0.14 NA
KWIC96 $0.13 NA $0.14 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
Rates For File: Derwent Drug File (1964-1982) - subscribers[913]
Standard Subscrib
Cost per DialUnit: $11.50 $12.65
Cost per Minute: $2.33 $2.57
Rank Elements $0.06 $0.07
<< Standard >> << Subscriber >>
Format Types Prints Types Prints
1 $0.00 $1.34 $0.00 $1.47
2 $1.34 $1.34 $1.47 $1.47
3 $1.34 $1.34 $1.47 $1.47
4 $1.34 $1.34 $1.47 $1.47
5 $1.34 $1.34 $1.47 $1.47
6 $0.00 $1.34 $0.00 $1.47
7 $1.34 $1.34 $1.47 $1.47
8 $0.00 $1.34 $0.00 $1.47
9 $1.34 $1.34 $1.47 $1.47
66 $1.26 $1.26 $1.39 $1.39
KWIC95 $0.13 NA $0.14 NA
KWIC96 $0.13 NA $0.14 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
