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Last Loaded on Web: Wednesday, May 01, 2013
Science, published by the American Association for the Advancement of Science (AAAS), serves its readers as a forum for the presentation and discussion of important issues related to the advancement of science. Emphasis is on material pertaining to the interactions among science, technology, government, and society. The peer-reviewed section of the journal presents cutting-edge research of either interdisciplinary interest or unusual significance to the specialist. Topical coverage reflects the range of AAAS’s interest across the physical, biological, and social sciences. Major sections of the journal are This Week in Science, News and Comments, Research News, Articles, Research Articles, and Reports. Science also includes book reviews, editorial and letters sections, policy forums, perspectives, and information about new techniques and instrumentation.
USE FILE 370to locate articles related to science with particular emphasis on interactions among science, technology, government, and society. USE RANKto rank AU to locate experts in specific fields: S MICROBIOLOGY/TIRANK AU USE SH=, /SHto find article published in a desired section. S SH=REPORTS POLICY(W)FORUMS/SH S (REPORTS OR ARTICLES)/SH Reports and Articles are the longer peer reviewed research articles. USE FORMAT 9for the complete text of all articles. Articles in SH= Editorials, Random Samples, Sciencescope, and This Week in Science default to Format 5, a less expensive format. Articles in SH= Book Reviews, Perspectives, News, News and Comments, and Research News default to Format 29, an intermediate price between Format 5 and 9. |
Science includes the following topics:
Science
| Dates Covered: | January 1996 to the present |
|---|---|
| File Size: | 3,510 records as of March 1998 |
| Update Frequency: | Closed |
| ACRONYM | CATEGORY NAME |
|---|---|
| ASTRON | Astronomy |
| BIOCHEM | Biochemistry |
| BIOSCI | Biosciences |
| BIOTECH | Biotechnology |
| CHEMLIT | Chemical Literature |
| ENERGY | Energy |
| ENERGYA | Energy Files + Ei EnCompass files |
| ENERGYP | Energy Files + TULSA |
| ENVIRON | Environment |
| MATERIAL | Materials |
| MEDICINE | Medicine |
| PHYSICS | Physics |
| SCITECH | Science and Technology |
|
Science is provided by AAAS. Questions concerning file content should be directed to: James Landry, Production Director 1200 New York Avenue, N.W. Washington, DC 20005
|
Science is copyrighted by the American Association for the Advancement of Science. For Dialog's Redistribution and Archive policy, enter HELP ERA online.
| DIALOG(R)File 370:SCIENCE | |
| (c) 1997 AAAS. All rts. reserv. | |
| 00000353 (THIS IS THE FULLTEXT) | |
| /TI, /XF | IMMUNOLOGY: Antigen Presentation: A Balanced Diet |
| AU= | Brenner, Michael; Porcelli, Steven |
| SO=, JN= | Science Vol. 277 No. 5324 pp. 332 |
| PD=, PY= | Publication Date: 07/18/97 (970718) Publication Year: 1997 |
| DT=, SN= | Document Type: Journal ISSN:0036-8075 |
| LA= | Language: English |
| /SH, SH=, /XF | Subject Heading: Perspectives |
| WD= | Word Count: 904 |
| /AB, /XT, /XF | Extract: IMMUNOLOGY: |
| Update: Antigen Presentation: A Balanced Diet | |
| Michael Brenner and Steven Porcelli | |
| CD1 molecules are distant cousins of major histocompatibility complex | |
| (MHC) molecules; both are located on the cell surface, and MHC binds or | |
| "displays" foreign peptides so that the immune system can recognize and | |
| eliminate them. In their Perspective, Brenner and Porcelli discuss the | |
| crystal structure of CD1 , reported by Zeng et al . in this issue. The new | |
| work shows how the structure of CD1 is specialized for presenting another | |
| class of antigens-lipids. | |
| ------------------------------------------------------------ | |
| The authors are in the Division of Rheumatology, Immunology, and Allergy, | |
| Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, | |
| USA. E-mail (M.B.): emontes@ bics.bwh.harvard.edu | |
| /TX | Text: IMMUNOLOGY: |
| Update: Antigen Presentation: A Balanced Diet | |
| Michael Brenner and Steven Porcelli | |
| For much of the past decade, immunologists studying how the immune | |
| system recognizes foreign molecules have focused on the molecular | |
| mechanisms by which T cells recognize peptide antigens. A series of | |
| landmark crystallographic studies have revealed how peptide antigens are | |
| displayed on the surface of cells. Amino acid side chains of the peptide | |
| are anchored into specific pockets in the peptide binding grooves of the | |
| major histocompatibility complex (MHC) class I and class II membrane | |
| proteins. This determines which peptides can bind MHC, and thus which | |
| peptides have the potential to be recognized by T cell receptors. However, | |
| several remarkable findings suggest that an important part of the story has | |
| not yet been told. On page 339 of this issue, Zeng et al . present the | |
| three-dimensional structure of murine CD1d1, a representative of a family | |
| of conserved mammalian proteins that are distant cousins of MHC molecules | |
| (1) (see figure). This structure reinforces the view that CD1 proteins bind | |
| and present antigen in a way that offers T cells a fundamentally different | |
| look at the antigenic universe, one that includes lipids and glycolipids. | |
| References and Notes: | |
| /CR, /TX, /XF | References |
| * Z. H. Zeng et al., Science 277, 339 (1997). | |
| * F. Calabi et al., in Immunogenetics of the Major Histocompatibility | |
| Complex, R. Srivastava, Ed. (VCH, Cambridge, United Kingdom, 1991), pp. | |
| 215-243. | |
| * S. A. Porcelli, Adv. Immunol. 59 , 1 (1995) [Medline]. | |
| * Image Removed | |
| , C. T. Morita, M. B. Brenner, Nature 360, 593 (1992) [Medline]. | |
| * E. Beckman et al., ibid. 372, 691 (1994) [Medline]. | |
| * P. A. Sieling et al., Science 269, 227 (1995) [Medline]. | |
| ------------------------------------------------------------ | |
| The authors are in the Division of Rheumatology, Immunology, and Allergy, | |
| Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, | |
| USA. E-mail (M.B): emontes@ bics.bwh.harvard.edu | |
| /DE, /XF | Descriptors: IMMUNOLOGY |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields | Word | S HISTOCOMPATIB? |
| /AB | AB | Abstract1 | Word | S IMMUNE(W)SYSTEM/AB |
| /CR | CR | Cited References2 | Word | S Z(1N)ZENG(S)SCIENCE/CR |
| /DE | DE | Descriptor3 | Word & Phrase |
S IMMUNOLOGY/DE S CELL NEURO/DE |
| /SH | SH | Section Heading4 | Word | S PERSPECTIVES/SH |
| /TI | TI | Title | Word | S BALANCED(W)DIET/TI |
| /TX | TX | Text | Word | S MYCOLIC(W)ACID?/TX |
| /XF | None | All Basic Index Fields Except Full Text | Word | S ANTIGEN(W)PRESENTATION/XF |
| /XT | XT | Extract1 | Word | S CELL(W)SURFACE?/XT |
1 Abstract and Extract are both searched using /AB or /XT.
2 Use the S-operator, (S), between items that are within the same reference.
4 Searchable in the Basic Index and in the Additional Indexes.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | AN | DIALOG Accession Number | ||
| AU= | AU | Author | Phrase | S AU=BRENNER, MICHAEL? |
| None | AZ | DIALOG Accession Number | ||
| CS= | CS | Corporate Source5 | Word & Phrase |
S CS=(HARVARD(W)MEDICAL(W)SCHOOL) S CS=THE AUTHORS ARE IN THE DIVISION OF? |
| DT= | DT | Document Type | Phrase | S DT=JOURNAL |
| JN= | JN | Journal Name | Phrase | S JN=SCIENCE |
| LA= | LA | Language | Phrase | S LA=ENGLISH |
| PD= | PD | Publication Date | Phrase | S PD=970718 |
| PY= | PY | Publication Year | Phrase | S PY=1997 |
| SH= | SH | Section Heading4 | Phrase | S SH=PERSPECTIVES |
| SN= | SN | International Standard Serial Number (ISSN) | Phrase | S SN=0036-8075 S SN=00368075 |
| SO= | SO | Source Information6 | Word | S SO=(SCIENCE AND 277 AND 5324 AND 332) |
| UD= | None | Update | Phrase | S UD=9999 |
| WD= | WD | Word Count | Numeric | S WD>=500 |
5 Corporate Source is not searchable with CS= from the following Section Headings: Book Reviews, News, News and Comments, Perspectives, Random Samples, Research News, and This Week in Science. Search the Corporate Source from these Section Headings free text in the Basic Index.
6 Display includes Journal Name, Volume, Issue and Pagination.
| SUFFIX | FIELD NAME | EXAMPLES |
|---|---|---|
| /ENG | English-Language Records | S S1/ENG |
| /FULLTEXT | Full Text | S S2/FULLTEXT |
| /LONG | Word Count of 1,000 words or more | S S6/LONG |
| /NONENG | Non-English Language Records | S S3/NONENG |
| /SHORT | Word Count of less than 1,000 words | S S5/SHORT |
| /YYYY | Publication Year | S S2/1996:1997 |
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| AU, JN, PD, PY, SH, TI | SORT S6/ALL/TI |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: DE | RANK AU RANK SH S4 |
| Display codes listed in the Search Options tables can be used to customize output. | TYPE S4/TI,AU,SH/1-5 |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Bibliographic Citation and Indexing |
| 3 | Medium | Bibliographic Citation |
| 4 | -- | Full Record except Text with Tagged Fields |
| 5 | Long | Full Record Except Text |
| 6 | Free | Title, Publication Date, and Word Count |
| 7 | -- | Full Record except Text and Indexing |
| 8 | Short | Title, Indexing, Publication Date, and Word Count |
| 9 | Full | Full Record |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| If the accession number of a specific record is known, it cn be used to display the record directly. | TYPE 00085603/9 DISPLAY 00056398/3,TX PRINT 00095905/9 |
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Rates For File: Science[370]
Cost per DialUnit: $4.46
Cost per minute: $1.47
Rank Elements $0.00
Format Types Prints
1 $0.00 $0.00
2 $2.00 $2.00
3 $2.00 $2.00
4 $2.00 $2.00
5 $2.00 $2.00
6 $0.00 $0.00
7 $2.00 $2.00
8 $0.00 $0.00
9 $5.00 $5.00
19 $14.00 $14.00
29 $3.25 $3.25
39 $5.50 $5.50
KWIC95 $0.17 NA
KWIC96 $0.18 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
