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Last Loaded on Web: Thursday, May 01, 2008
Current Biotechnology Abstracts database corresponds to the printed publication Current Biotechnology formerly produced by The Royal Society of Chemistry and contains all of the material published in the hard-copy version since its start-up in April 1983. From January 2000 forward, the database is produced by the Deutsche Gesellschaft fur Chemisches Apparatewesen (DECHEMA). Records contain bibliographic details, an informative abstract, and subject, chemical, and company indexes designed for ease of online searching. Documents indexed cover technocommercial news, scientific and technical items (including patents), and general information (forthcoming events, book announcements etc.).
USE FILE 358to find information on all aspects of biotechnology. USE /ABto search both the English and German langauage abstracts. SELECT (SEWAGE OR ABWASSER)/ABUSE AE DISPLAY CODEto display only the English language abstract. TYPE S1/AE/1USE AG DISPLAY CODEto display only the German language abstract. TYPE S2/AG/ALL |
Current Biotechnology Abstracts covers all aspects of biotechnology, including:
A core source of nearly 200 primary and news journals is supplemented by European, U.S., PCT, and UK patents, press releases, conference proceedings, and announcements of books, technical reports, meetings, and other matters pertaining to biotechnology.
| Dates Covered: | April 1983 to January 2006 |
|---|---|
| File Size: | 131,832 records as of January 2006 |
| Update Frequency: | Closed - Use File 315 |
| ACRONYM | CATEGORY NAME |
|---|---|
| BIOBUS | Biosciences and Biotechnology Industry |
| BIOTECH | Biotechnology |
|
Current Biotechnology Abstracts is produced by Deutsche Gesellschaft fur Chemisches Apparatewesen (DECHEMA). Questions concerning file content should be directed to: Information Systems and Databases DECHEMA Theodor-Heuss-Allee 25 Frankfurt am Main, D 60486 Germany
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These databases are copyrighted by Deutsche Gesellschaft fur Chemisches Apparatewesen (DECHEMA). These databases may not be copied in entirety. Portions of the databases may not be copied such as to have the effect of avoiding use charges for the databases. Except as expressly stated in Dialog's Redistribution and Archive Policy, copies may not be offered for resale. DECHEMA shall use its best endeavours to ensure that the information contained in the databases is accurate and up-to-date, but DECHEMA accepts no liability for omissions or errors therein or their consequences.
| DIALOG(R)File 358:Current BioTech Abs | |
| (c) 2003 DECHEMA . All rts. reserv. | |
| AX=, DT= | 123423 CBA Acc. No.: 21-09-005051 DOC. TYPE: Journal |
| /TI | Lonza: 20 years of biotransformations |
| Orig. Title: Lonza: 20 Jahre Biotransformationen | |
| AU= | AUTHOR: Shaw, N.M. ; Robins, K.T. ; Kiener, A. |
| CS=, SO= | CORPORATE SOURCE: LONZA AG, Visp, CH |
| JN=, SO= | JOURNAL: Adv. Synth. Catal. Volume: 345 Issue: 4 Page(s): 425-435 |
| CD=, SN= | CODEN: ASCAF7 ISSN: 16154150 |
| PD=, PY= | PUBLICATION DATE: 2003 (20030000) |
| /AB | ABSTRACT: The present review deals with biotransformations by which the |
| custom manufacturer Lonza produces intermediates for life science | |
| companies and especially pharmaceutical companies. Reactions catalysed | |
| by microorganisms and/or enzymes are understood as biotransformations; | |
| the microorganisms can be wild-type or recombinant, free or | |
| immobilised. Biotransformations are usually used for the synthesis of | |
| chiral molecules as well as for reactions that are chemically | |
| impossible or difficult to carry out. In the text, the syntheses of the | |
| following substances as intermediates of pharmaceuticals done at Lonza | |
| as well as the rationales for the use of biocatalysts are presented: | |
| --oxidations oxidation of alkyl groups on aromatic heterocycles | |
| -5-methylpyrazine-2-carboxylic acid -pyridyl-3-acetic acid | |
| regiospecific hydroxylations of aromatic N-heterocycles | |
| -6-hydroxynicotinic acid --reductions -(R)-ethyl-4,4,4-trifluoro-3 | |
| -hydroxybutanoate --hydrolysis -nicotinamide -(S)-pipecolic acid | |
| and (S)-piperidine-2-carboxylic acid -CBZ-D-proline and | |
| (R)-N-CBZ-proline -(1R,4S)-1-amino-4-hydroxymethylcyclopent-2-ene | |
| -(S)-2,2-dimethylcyclopropanecarboxamide -(S)-3,3,3-trifluoro-2-hydro | |
| xy-2-methylpropionic acid --multi-enzyme-biotransformations | |
| -L-alaninol -L-carnithine. | |
| ABSTRACTOR: Grohs, Birgit-Maria (FAH, Sinzig) | |
| /AB | ABSTRACT: Die Verf. befassen sich mit Biotransformationen, durch die der |
| Auftragshersteller Lonza Intermediate fuer Unternehmen der | |
| Lebenswissenschaften und insbesondere pharmazeutische Unternehmen | |
| produziert. Dabei werden unter Biotransformationen Reaktionen | |
| verstanden, die von Mikroorganismen und/oder Enzymen katalysiert | |
| werden; die Mikroorganismen und/oder Enyzme koennen vom Wildtyp oder | |
| rekombinant sein, frei oder immobilisiert vorliegen. In der Regel | |
| werden Biotransformationen zur Synthese chiraler Molekuele sowie bei | |
| Reaktionen eingesetzt, die auf chemischem Weg nicht oder nur schwer | |
| zugaenglich sind. Es werden die bei Lonza durchgefuehrten Synthesen | |
| der folgenden Substanzen als Intermediate von Arzneimitteln sowie die | |
| Rationalen fuer die Verwendung von Biokatalysatoren vorgestellt: | |
| --Oxidationen Oxidation von Alkylgruppen an aromatischen Heterozyklen | |
| -5-Methylpyrazin-2-carbonsaeure -Pyridyl-3-essigsaeure Regiospezifi | |
| sche Hydroxylierung von aromatischen N-Heterozyklen | |
| -6-Hydroxynicotinsaeure --Reduktionen -(R)-Ethyl-4,4,4-trifluor-3-hy | |
| droxybutanoat --Hydrolysen -Nicotinamid -(S)-Pipecolinsaeure und | |
| (S)-Piperidin-2-carbonsaeure -CBZ-D-Prolin und (R)-N-CBZ-Prolin | |
| -(1R,4S)-1-Amino-4-hydroxymethylcyclopent-2-en -(S)-2,2-Dimethylcyclop | |
| ropancarboxamid -(S)-3,3,3-Trifluor-2-hydroxy-2-methylpropionsaeure | |
| --Multi-Enzym-Biotransformationen -L-Alaninol -L-Carnithin. | |
| ABSTRACTOR: Grohs, Birgit-Maria (FAH, Sinzig) | |
| NO. OF PAGES: 11 | |
| NO. IN PRINT: 0310/280 | |
| NO. OF FIGURES: 17 | |
| NO. OF TABLES: 1 | |
| NO. OF SOURCES: 57 | |
| /DE | DESCRIPTORS: review ; biotransformation ; microorganism ; enzyme ; |
| pharmaceutical | |
| /DE | DESCRIPTORS: Biotransformation ; Mikroorganismen ; Enzym ; Arzneimittel |
| ; Lonza | |
| /SH, SH=, SC= | SECTION: Enzymology and Biotransformation (55) |
| /DN, DN=, DC= | DECHEMA CLASSIFICATION: Biochemical and microbiological processes (5830) |
| ; Basic chemicals (9433 ) | |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields | Word | S BIOTRANSFORMATION?(F)REVIEW |
| /AB | AB | Abstract1 | Segment & Word |
S METHYL/AB S BIO?ATALY?(5N)OXIDAT?/AB |
| None | AE | Abstract in English | ||
| None | AG | Abstract in German | ||
| /DE | DE | Descriptor1,2 | Segment & Word & Phrase |
S ENZYME/DE S MIKROORGANISMEN/DE S REVIEW/DE S ENZYME/DE S MIKROORGANISMENDE S ALGAL BIOMASS/DE |
| /SH | SH | Section Name3,4 | Word & Phrase |
S ENZYMOLOGY/SH S 'ENZYMOLOGY AND BIOTRANSFORMATION'/SH |
| /TI | TI | Title1 | Segment & Word |
S LONZA/TI S LONZA(F)BIOTRANSFORMATION?/TI |
1 Chemical substance names are segmented in all Basic Index fields; for example, TRINITROBENZENE is retrieved when searched as a single term or by searching the segments: TRI, NITRO, or BENZENE. To exclude the segments use the /FW suffix; e.g., S BENZENE/FW to retrieve the word set off by spaces or punctuation marks.
2 Includes descriptors and chemical substances; chemical substances are also searchable using SY=.
3 Includes Section cross-reference name.
4 Also searchable using SH= or XR=.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| AD= | AD | Patent Application Date13 | Phrase | S AD=19970922 |
| AL= | AL | Abstract Language | Phrase | S AL=FRENCH |
| AN= | AN | Patent Application Number13 | Phrase | S AN=FR 9711757 |
| None | AR | Abstractor | ||
| AU= | AU | Author | Phrase | S AU=SHAW, N.M. |
| AV= | AV | Availability | Word | S AV=OJPS |
| AX= | AX | CBA Abstract Number | Phrase | S AX=21-09-005051 |
| None | AX | DIALOG Accession Number | ||
| BN= | BN | International Standard Book Number (ISBN) | Phrase | S BN=3-527-30759-1 S BN=3527307591 |
| CD= | CD | CODEN | Phrase | S CD=ASCAF7 |
| CF= | CF | Conference Information11 | Word | S CF=(ACS AND BOULDER AND 1982) |
| CO= | CO | Source Organization5,12 | Word & Phrase |
S CO=(PROTEOME(W)SCIENCES) S CO=PROTEOME SCIENCES PLC S CO=PROTEOME(W)SCIENCES) S CO=PROTEOME SCIENCES PLC |
| CS= | CS | Corporate Source5 | Word | S CS=(LONZA(W)AG) |
| CT= | CT | Secondary Citation5,11 | Word | S CT=(CHEM(W)ABSTR(W)110(W)04) |
| DT= | DT | Document Type | Phrase | S DT=JOURNAL |
| None | ED | Book Editorial Information | ||
| JN= | JN | Journal Name | Phrase | S JN=ADV. SYNTH. CATAL. |
| LA= | LA | Language | Phrase | S LA=ENGLISH |
| None | NF | Number of Figures14 | ||
| None | NP | Number in Print14 | ||
| None | NS | Number of Sources14 | ||
| None | NT | Number of Tables14 | ||
| PD= | PD | Publication Date | Phrase | S PD=20030000 |
| None | PG | Number of Pages14 | ||
| PN= | PN | Patent Number13 | Phrase | S PN=EP 0077856 |
| PU= | PU | Publisher5 | Word | S PU=(J(W)WILEY) |
| None | PU | Publisher Address | ||
| PY= | PY | Publication Year | Phrase | S PY=2003 |
| RN= | RN | Report Number12 | Phrase | S RN='GKSS 99/E/18' |
| RT= | RT | Report Title | Word | S RT=KERNENERGIEVERWERTUNG |
| SC= | SC | Section Code6 | Phrase | S SC=55 |
| SH= | SH | Section Name7 | Phrase | S SH='ENZYMOLOGY AND BIOTRANFORMATION' |
| SN= | SN | International Standard Serial Number (ISSN) | Phrase | S SN=16154150 |
| None | SO | Editorial Information | ||
| SO= | SO | Source Information8 | Word | S SO=LONZA S SO=(LONZA(F)VISP) |
| SY= | SY | Chemical Synonyms9,12 | Phrase | S SY=ALDEHYDE OXIDASE |
| UD= | None | Update | Phrase | S UD=9999 |
| XR= | XR | Cross-Reference Section Name/Section Code10 | Phrase | S XR=CHEMICAL INDUSTRY |
6 Searches both section and cross reference section codes; SC display outputs only section code; XR display outputs only cross reference section code.
7 Searches section name only. Use XR= to search cross reference section name.
8 Display includes Availability, Conference Information, Corporate Source, Journal Name, Secondary Citation, Publication Date, Report Title, Report Number, and Publisher Data as appropriate.
10 Display outputs both cross-reference section name and code.
11 Available through the end of 1989 only.
12 Available through the end of 1999 only.
13 Patent coverage stopped in 1999.
| Sets and terms may be limited by Basic Index suffixes, i.e., /AB, /DE, /SH, /TI (e.g. SELECT S3/TI). | ||
| SUFFIX | FIELD NAME | EXAMPLES |
|---|---|---|
| / | DIALOG Accession Number | S S5/0120318-9999999 |
| /CONF | Conference11 | S S1/CONF |
| /ENG | English Language | S S3/ENG |
| /NONENG | Non-English Language | S S4/NONENG |
| /NPT | Non-Patent Records13 | S S1/NPT |
| /PAT | Patent Records13 | S S1/PAT |
| /YYYY | Publication Year | S S2/1999-2003 |
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| AU, CS, JN, PD, PY, SH, TI | SORT S3/ALL/JN/AU PRINT S4/5/1-23/PY |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: DE | RANK DE RANK AU S4 |
| MAP FIELDS | EXAMPLES |
|---|---|
| CD, PN, SN, SY | MAP PN TEMP S1 |
| Display codes listed in the Search Options tables can be used to customize output. | TYPE S3/TI,AU,JN,PY/ALL |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Full Record except Abstract |
| 3 | Medium | Bibliographic Citation |
| 4 | -- | Full Record with Tagged Fields |
| 5 | -- | Full Record |
| 6 | Free | Title |
| 7 | Long | Full Record except Indexing |
| 8 | Short | Title and Indexing |
| 9 | Full | Full Record |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| If the accession number of a specific record is known, it can be used to display the record directly. | TYPE 011438/5 DISPLAY 011372/TI,SO PRINT 011223/5 |
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Rates For File: Current Biotechnology Abstracts[358]
Cost per DialUnit: $3.90
Cost per minute: $1.35
Rank Elements $0.00
Format Types Prints
1 $0.00 $0.00
2 $3.57 $3.57
3 $3.57 $3.57
4 $3.57 $3.57
5 $3.57 $3.57
6 $0.00 $0.00
7 $3.57 $3.57
8 $0.00 $0.00
9 $3.57 $3.57
KWIC95 $0.00 NA
KWIC96 $0.00 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
