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Last Loaded on Web: Thursday, May 01, 2008
Derwent Biotechnology Resource, formerly Derwent Biotechnology Abstracts, produced by Thomson Derwent and Institute for Scientific Information (ISI), provides comprehensive coverage of journal articles, patents, and conference proceedings describing research in the field of biotechnology. It covers all aspects of biotechnology, including genetic engineering, biochemical engineering, fermentation, cell culture and waste disposal. Beginning in 2002 coverage has been expanded to include bioinformatics, functional genomics, pharmacogenomics, high throughput screening, biochips, and tissue engineering. Each month data from about 3,000 documents are added to the file in weekly updates. The number of records per update will increase throughout 2002. Each record in the database contains a detailed abstract together with controlled-language indexing, including an enhanced classification system from 2002 forward. Patent coverage is enhanced with complete Derwent World Patents Index® abstracts from June 2002 forward. Approximately 37 percent of the records are patent records. Literature records also include complete bibliographic information and author abstracts, which are provided by ISI from June 2002 forward.
USE FILE 357to find journal articles and patents in all aspects of biotechnology. USE SH=to search Section Headings and Subheadings SELECT SH=GENOMIC TECHNOLOGIESUSE LIMIT suffixes /PAT or /NPTto separate search results into patents and nonpatents. SELECT S2/PAT
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Coverage in Derwent Biotechnology Resource includes, but is not limited to:
Over 1,100 journals published in 20 languages are regularly and promptly scanned for relevant papers. The journal list has been revised to include the very latest journals in biotechnology. The new journal list is prioritized to ensure that the highest yielding and most relevant scientific journals are available online first. In addition, the worldwide biotechnology patents literature from Derwent World Patents Index® and conference proceedings are also covered.
| Dates Covered: | 1982 to the present |
|---|---|
| File Size: | 329,189 records as of March, 2004 |
| Update Frequency: | Weekly |
The following search aid is available in the Dialog Library:
Derwent Biotechnology Resource, File 357 Section Headings and Subheadings
| ACRONYM | CATEGORY NAME |
|---|---|
| AGRI | Agriculture |
| BIOSCI | Biosciences |
| BIOTECH | Biotechnology |
| HEALTH | Health |
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Derwent Biotechnology Resource is produced by Thomson Scientific. Questions concerning file content should be submitted by Web Form at www.thomsonscientific.com/support/techsupport or directed to: 14 Great Queen Street London, WC2B 5DF United Kingdom
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For Dialog's Redistribution and Archive Policy, enter HELP ERA online. The following terms and conditions also apply.
Derwent Biotechnology Resource: Database copyrighted by Thomson Derwent and Institute for Scientific Information. For non-subscribers, redistribution is permitted in accordance with Dialog's ERA redistribution program. Redistribution for subscribers within sites covered by a Derwent subscription is already a benefit of that subscription.
| DIALOG(R)File 357:Derwent Biotech Res. | |
| (c) 2002 Derwent Info & ISI. All rts. reserv. | |
| AZ= | 0291502 DBA Accession No.: 2002-13349 |
| /TI | Selective enzymatic epoxidation of dienes: generation of functional |
| enantiomerically enriched diene monoepoxy monomers - Pseudomonas sp. | |
| oxidase and Caldariomyces fumago chloroperoxidase for methacrylate, | |
| acrylate, dimethylhexadiene and divinylbenzene epoxidation for | |
| stereospecific compound production | |
| AU= | AUTHOR: HU SH; GUPTA P; PRASAD AK; GROSS RA; PARMAR VS |
| CS= | CORPORATE AFFILIATE: Polytech Univ Univ Delhi |
| CS= | CORPORATE SOURCE: Gross RA, Polytech Univ, Dept Chem, NSF, Ctr Biocatalysis |
| and Bioproc Macromol, 06 Metrotech Ctr, Brooklyn, NY 11201 USA | |
| SO=, JN=, PY= | JOURNAL: TETRAHEDRON LETTERS (43, 38, 6763-6766) 2002 |
| SN= | ISSN: 0040-4039 |
| LA= | LANGUAGE: English |
| /AB | ABSTRACT: AUTHOR ABSTRACT - Enantiomerically enriched diene monoepoxides |
| were selectively synthesized using oxidases from Pseudomonas sp. and | |
| chloroperoxidase from Caldariomycesfumago. These monoepoxides are | |
| useful monomers for generating functional chiral polymeric materials. | |
| (C) 2002 Elsevier Science Ltd. All rights reserved. DERWENT ABSTRACT: | |
| Divinylbenzene epoxidation was carried out in n-octane-based two-phase | |
| bioreactor system, using oxidases from Pseudomonas putida. 0.25 g | |
| Divinylbenzene in 20 ml n-octane was added into 1 l of culture medium | |
| of P. putida and the progress of the reaction was monitored by TLC and | |
| gas chromatography. After 72 hr of incubation the culture was extracted | |
| with ether, the organic layer was separated, dried and evaporated, to | |
| afford the crude product, which was purified by flash-column | |
| chromatography. 30% Of products were achieved and physical and spectral | |
| data of the divinylbenzene monoepoxides were determined. Methacrylate, | |
| acrylate and dimethylhexadiene was stirred with t-BuOOH in 2 ml of 10 | |
| mM sodium citrate buffer (pH 5.5) and 200 ul acetone. 2.5 mg | |
| Caldariomyces fumago chloroperoxidase (EC-1.11.1.10) was added and the | |
| reaction mixture was stirred at RT for 2 hr, after which Na2S03 was | |
| added and the mixture was extracted with ether. The combined organic | |
| portions were dried over MgSO, the ether removed and the crude product | |
| was purified by flash-column chromatography using dichloromethane as | |
| eluting solvent to afford the pure epoxides 73-87% yields and 81-97% | |
| enantiomeric excesses(4 pages) | |
| EC= | E.C. NUMBERS: 1.11.1.10 |
| /DE | DESCRIPTORS: stereospecific diene monoepoxide prep., divinylbenzene, |
| unsaturated methacrylate, acrylate, dimethylhexadiene epoxidation, | |
| Pseudomonas sp. oxidase, Caldariomyces fumago, chloroperoxidase | |
| reactor, TLC, gas chromatography, appl. chromatography support polymer | |
| bacterium fungus enzyme EC-1.11.1.10 bioreactor (21, 41) | |
| /SH, SH= | SECTION: OTHER CHEMICALS-Stereospecific Compounds-BIOMANUFACTURING and |
| BIOCATALYSIS-Biocatalyst Application; BIOMANUFACTURING and | |
| BIOCATALYSIS-Biochemical Engineering | |
| DIALOG(R)File 357:Derwent Biotech Res. | |
| (c) 2002 Thomson Derwent & ISI. All rts. reserv. | |
| AZ= | 0284360 DBA Accession No.: 2002-06207 PATENT |
| /TI | Producing animals using embryonic stem cells which originate from cloned |
| embryo in nuclear transfer procedure, useful to produce agricultural | |
| animals and endangered species - embroyonic stem cell nuclear transfer | |
| into host egg for the production of cattle, primate, sheep, pig, dog, | |
| cat, goat, fowl, turkey, guinea-hen, ostrich, eagle and osprey | |
| AU= | AUTHOR: WEST M D |
| PA= | PATENT ASSIGNEE: ADVANCED CELL TECHNOLOGY INC 2001 |
| PC=, PN=, PD=, | PATENT NUMBER: WO 200184920 PATENT DATE: 20011115 WPI ACCESSION NO.: |
| AX=, DW= | 2002-075220 (200210) |
| AC=, AN=, AD= | PRIORITY APPLIC. NO.: US 567437 APPLIC. DATE: 20000510 |
| AC=, AN=, AD= | NATIONAL APPLIC. NO.: WO 2001US15075 APPLIC. DATE: 20010510 |
| LA= | LANGUAGE: English |
| /AB | ABSTRACT: DERWENT ABSTRACT: NOVELTY - An animal produced from embryonic |
| stem (ES) cells (I) which originate from a cloned embryo, is new. | |
| DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for the | |
| following: (1) poultry, mammals and farm animals produced from (I); (2) | |
| ES cells produced from an embryo made by nuclear transfer; (3) a | |
| business model whereby cryopreserved clonal ES cells are marketed | |
| instead of live animals for the production of farm animals; (4) | |
| producing (M1) an ES-derived cloned mammal, comprising: (a) isolating a | |
| somatic cell from an animal with desired characteristics; (b) | |
| transfecting the cell with a positive selection marker; (c) using the | |
| cell as a cell or nuclear donor during a nuclear procedure; (d) | |
| culturing the resultant nuclear transfer embryo to develop into a | |
| blastocyst or post-blastocyst stage embryo; (e) isolating totipotent | |
| from the embryo and expanding the cells in culture to produce ES cells; | |
| (f) optionally cryopreserving the expanded ES cells; (g) inserting the | |
| ES cells into a host embryo of 1-200 cells which is not resistant to | |
| the selectable marker; (h) culturing the resultant embryo under | |
| selective conditions for the marker to obtain embryos substantially | |
| consisting of cells that comprise the genome of ES cells; and (i) | |
| transferring the embryo to a recipient female; (5) deriving (M2) a | |
| cloned animal from an ES cell comprising: (a) isolating a somatic cell | |
| from an animal with desired characteristics; (b) using the cell as a | |
| cell or nuclear donor in nuclear transfer; (c) using the resultant | |
| nuclear transfer fusion to produce an embryo of the blastocyst stage or | |
| later; (d) isolating totipotent cells from the embryo and expanding | |
| them in culture to produce ES cells; (e) inserting some of the ES cells | |
| into a host embryo of 2-200 cells which is incapable of development; | |
| and (f) culturing the resultant embryo to a suitable size and | |
| transferring it into a recipient female; (6) producing (M3) an avian | |
| from ES cells comprising: (a) isolating ES cells from an avian with | |
| desired characteristics; (b) expanding the ES cells in culture and | |
| optionally cryopreserving the expanded cells; (c) obtaining eggs that | |
| are unable to develop into an embryo; (d) injecting the ES cells into | |
| the eggs; and (e) incubating the eggs to produce avian offspring with | |
| the genotype of the ES cells. BIOTECHNOLOGY - Preferred Method: In M1 | |
| about 2-20 ES cells are inserted into the host embryo which is a | |
| bovine, primate, ovine, porcine, canine, feline or caprine. In M2 the | |
| host embryo is a tetraploid and one of the species defined above, more | |
| preferably a cow. In M3 the avian is a chicken, turkey, guinea hen, | |
| ostrich, eagle, osprey, bird of prey or avian near extinction. In any | |
| of the methods the ES cell may be genetically modified. USE - The | |
| invention is used to produce animals, particularly agricultural | |
| animals, stem cell lines and endangered species. ADVANTAGE - The | |
| combination of nuclear transfer and ES cell technologies improves the | |
| efficiency of delivering optimized animals and facilitates the | |
| introduction of genetic modifications into farm animals. EXAMPLE - | |
| Bovine ovaries were recovered at a slaughterhouse and placed in | |
| phosphate buffered saline (PBS) at 34 degrees C. Follicles were | |
| aspirated and oocytes with a homogenous cytoplasm, considerable | |
| perivitelline space and intact cumulus cells were placed in maturation | |
| medium M199 (Gibco) with 10% fetal calf serum (FCS), 5 micro liter/ml | |
| bovine follicle-stimulating hormone and 10 micro liter/ml Pen-strep for | |
| (. . .) | |
| they were transferred to the same medium containing 10% FCS until | |
| blastocyst stage. Blastocysts were placed in mitotically inactivated | |
| mouse embryonic fibroblast (MF) feeder layer and embryonic stem (ES) | |
| cell medium and the zona pellucida and trophoblast were mechanically | |
| removed. The remaining inner cell mass (ICM) was placed under the MF. | |
| After 1 week in culture ES-like cells were passaged to a fresh | |
| mitotically inactivated MF. For nuclear transplantation oocytes 18 | |
| hours post-maturation were placed in TL HECM-Hepes under mineral oil | |
| (Sigma) an enucleated using standard technique. Donor cells were placed | |
| in the perivitelline space and fused with the eggs cytoplasm at 23 | |
| hours post maturation, and activated using standard techniques. (29 | |
| pages) | |
| /DE | DESCRIPTORS: cattle, primate, sheep, pig, dog, cat, goat, fowl, turkey, |
| guinea-hen, ostrich, eagle, osprey cloning, prep., embroyonic stem cell | |
| nuclear transfer, nuclear transplantation, cryopreservation, appl. | |
| agricultural animal,endangered sp. prep mammal bird preservation (21, | |
| 24) | |
| /SH, SH= | SECTION: THERAPEUTICS-Tissue Culture/Engineering-GENETIC TECHNIQUES and |
| APPLICATIONS-Gene Expression Techniques and Analysis; BIOMANUFACTURING | |
| and BIOCATALYSIS-Animal/Plant Cell Culture | |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields1 | Word | S FERTILI?ATION(1N)EMBRYO? |
| /AB | AB | Abstract | Segment & Word |
S CHLORO/AB S CHLOROPEROXIDASE/AB S CLONED(W)MAMMAL/AB |
| /DE | DE | Descriptor | Segment & Word |
S VINYL/DE S DIVINYLBENZENE/DE S ANIMAL(W)ENZYME/DE |
| /SH | SH | Section Heading2 | Word | S GENETIC(W)TECHN?/SH |
| /TI | TI | Title | Segment & Word |
S METHYL/TI S DIMETHYLHEXADIENE/TI S STEM(W)CELL?(F)PRIMATE/TI |
1 Chemical substance names are segmented in all Basic Index fields; for example, DICHLOROHEXANE is retrieved when searched as a single term or by searching the segments: DI, CHLORO, HEXANE or CHLOROHEXANE. To exclude the segments use the /FW suffix; e.g., S HEXANE/FW to retrieve the word set off by spaces or punctuation marks.
2 Searchable in the Basic Index and in the Additional Indexes.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| AC= | AN | Patent Application Country3 | Phrase | S AC=US |
| AD= | AD | Patent Application Date3 | Phrase | S AD=20000510 |
| AN= | AN | Patent Application Number3 | Phrase | S AN=US 567437 |
| AU= | AU | Author4 | Phrase | S AU=(PRASAD AK OR PRASAD A K) |
| AX= | AX | DWPI Accession Number8 | Phrase | S AX=2002-075220 S AX=1999-288710 S AX=99-351247 |
| AX= | AX | WPI Accession Number | Phrase | S AX=87-308092 |
| AY= | AY | DBR Accession Year | Phrase | S AY=98 |
| AZ= | AZ | DBR Accession Number | Phrase | S AZ=88-00618 |
| None | AZ | DIALOG Accession Number | ||
| CD= | CD | CODEN5,6 | Phrase | S CD=JCEBD5 |
| CF= | CF | Conference Information5,9 | Word | S CF=(BIOMOLECULAR(F)ELECTRONICS) |
| CS= | CS | Corporate Source10 | Word | S CS=(POLYTECH(W)UNIV(S)BROOKLYN) S CS=(ADVANCED(W)CELL(W)TECHNOL?) |
| DW= | DW | Derwent (DWPI) Week | Phrase | S DW=200210 |
| EC= | EC | Enzyme Commission Number | Phrase | S EC=1.11.1.10 |
| JN= | JN | Journal Name6,7 | Phrase | S JN=TETRAHEDRON LETT? |
| LA= | LA | Language | Phrase | S LA=ENGLISH |
| PA= | PA | Patent Assignee11 | Word & Phrase |
S PA=(ADVANCED(W)CELL(W)TECHNOL?) S PA=ADVANCED CELL TECH? |
| PC= | PC | Patent Country | Phrase | S PC=EP |
| PD= | PD | Patent Date | Phrase | S PD=20011115 |
| PN= | PN | Patent Number | Phrase | S PN=WO 200184920 |
| PY= | PY | Publication Year | Phrase | S PY=2001 |
| SC= | SC | Section Code12 | Phrase | S SC=M1 |
| SH= | SH | Section Heading2,13 | Phrase | S SH=BIOMANUFACTURING? |
| SN= | SN | International Standard Serial Number (ISSN)9 | Phrase | S SN=0040-4039 |
| SO= | SO | Source Information14 | Word | S SO=(TETRAHEDRON(W)LETT?) |
| UD= | None | Update | Phrase | S UD=9999 |
3 Includes data from both priority and national applications.
4 Beginning with UD=200206W1, Author names in non-patent records have no space between initials. Search both forms to cover the entire time span of the database.
5 Discontinued at the end of May, 2002.
6 May also be searched using JL= (Journal Information).
7 Beginning with UD=200206W1, Journal Names are indexed as complete names, not abbreviated. Search both forms, complete and abbreviated, to cover the entire time span of the database.
8 DWPI Accession Numbers have 4-digit year beginning with year 2000. Earlier DWPI Acession Numbers have 2-digit year, unless they were entered in File 357 after the beginning of 2000. Search DWPI Accession Numbers with both forms of the year if the accession number is in 1998 or 1999.
10 Includes patent assignee (PA=) and Corporate Affiliate.
11 May also be searched using CS= or CA= (Corporate Affiliate).
12 May also be searched using CL= (Class); SC= entries are cascaded to the first letter, e.g., S SC=M. Discontinued at the end of 2001.
13 New Section Headings, without corresponding Section Codes, begin with the first update of 2002.
14 Display includes Journal Name, Corporate Source, Patent Assignee, Publication Year and Cite Information.
| Sets and terms may be limited by Basic Index suffixes, i.e., /AB, /DE, /SH, /TI, (e.g., SELECT S4/TI). | ||
| SUFFIX | FIELD NAME | EXAMPLES |
|---|---|---|
| / | DIALOG Accession Number | S S1/0283036-9999999 |
| /ENG | English Language | S S7/ENG |
| /NONENG | Non-English Language | S S9/NONENG |
| /NPT | Non-Patent Records | S S8/NPT |
| /PAT | Patent Records | S S2/PAT |
| /YYYY | Publication Year | S S4/2001 |
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| AU, CS, JN, PD, PY, SH, TI | SORT S8/ALL/JN,AU PRINT S6/5/1-34/JN/PY,D |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. | RANK DE RANK AU S4 |
| MAP FIELDS | EXAMPLES |
|---|---|
| AN, AX, CD, EC, PN | MAP PN TEMP S2 |
| Display codes listed in the Search Options tables can be used to customize output. | TYPE S3/TI,AU,JN,PY/ALL |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Full Record except Abstract |
| 3 | Medium | Bibliographic Citation |
| 4 | -- | Full Record with Tagged Fields |
| 5 | -- | Full Record |
| 6 | Free | Title and Accession Numbers |
| 7 | Long | Full Record except Indexing |
| 8 | Short | Title and Indexing |
| 9 | Full | Full Record |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| If the accession number of a specific record is known, it can be used to display the record directly. | TYPE 001618/5 DISPLAY 002775/TI,SO PRINT 001623/5 |
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