307
Dictionary of Substances and Their Effects (DOSE)

Last Loaded on Web: Thursday, May 01, 2008

Last Update To Bluesheet: June 19, 2002

Bluesheet Contents     PDF version

File Description Dialog File Data Special Features Sample Record Sort Rates
Subject Coverage Database Content DIALINDEX/OneSearch Categories Basic Index Rank
Tips Document Types Indexed Contact Additional Indexes Map
Print Counterparts Geographic Coverage Terms and Conditions Limit Predefined Format Options


File Description [top]

The Dictionary of Substances and their Effects (DOSE) is a unique guide to the impact of chemicals on organisms and the environment. DOSE contains detailed records for more than 4000 chemicals. These chemicals have been selected from sources such as Europe's Black List and Grey List of dangerous substances, the UK's Red List, priority pollutant lists from the USA and Canada, and the pollutant list from Germany. Other chemicals which are reported to have adverse effects on the environment are also covered.



Tips [top]

USE FILE 307

to identify the hazards of chemicals to both mammals and the environment and to make rapid hazard assessment on a chemical which leads to risk assessment and beyond.

USE MAP

to expand a search to other databases. Use SY (Synonyms), RN (CAS® Registry Number), or SYRN (combination of both) as the field(s) to be extracted from records into a SearchSave, which is then executed in other files.

     MAP SYRN TEMP
     BEGIN TOXICOL; EXS

USE /NA, NA=

to isolate a particular chemical or substance by name.

     EXPAND NA=1,8-ETHYLENENAPHTHALENE

USE RN=

to retrieve substances by CAS® Registry Number.



Subject Coverage [top]

DOSE includes the following data and information:

  • CAS® Registry Number
  • Chemical Name and Synonyms
  • Chemical Name and Synonyms
  • Environmental Fate: Abiotic Removal; Absorption; Anaerobic Effects; Carbonaceous Inhibition; Degradation Studies; Nitrification Inhibition
  • Physical and Chemical Properties
  • Reference List
  • Regulatory Information: Conveyance Classification; EINECS/ELINCS Numbers; HAZCHEM Code; Occupational Exposure; Limit Values; Risk and Safety Phrases; RTECS Numbers; Supply Classification; UN Number
  • Toxicity: Ecotoxicity which includes Fish Toxicity; Invertebrate Toxicity; Bioaccumulation Data; Mammalian and Avian Toxicity which includes Carcinogenicity and Long-term Effects; Genotoxicity; Irritancy; Metabolism and Pharmacokinetics; Sensitisation; Teratogenicity and Reproductive Effects; Other Adverse Effects
  • Uses


Print Counterparts [top]

  • The Dictionary of Substances and their Effects


Dialog File Data [top]

Dates Covered: Current
File Size: 4,123 records as of March 2001
Update Frequency: Closed


Database Content [top]

  • Numeric Data
  • Complete Text Records


Document Types Indexed [top]

  • Chemical Substances


Geographic Coverage [top]

  • International


Geographic Restrictions [top]

  • None


Special Features [top]

  • Graduate Education Program
  • KWIC and HILIGHT Available
  • MAP Available


DialIndex/OneSearch Categories [top]

ACRONYM CATEGORY NAME
CASREGNO CAS(R) Registry Numbers-Chemical and Medical Files
CHEMPROP Chemical Properties
CHEMREGS Chemical Regulation
CHEMSUBS Chemical Substances
PHARMR Pharmacology + RINGDOC-Files
REGS Regulations
RNCHEM CAS(R) Registry Numbers - Chemistry Files
SAFETY Safety
TOXHAND Toxicity Handbooks
TOXICOL Toxicology


Contact [top]

The Dictionary of Substances and their Effects (DOSE) database is provided by the Royal Society of Chemistry. Questions concerning file content should be directed to:

The Royal Society of Chemistry
Thomas Graham House, Science Park, Milton Road
Cambridge,
United Kingdom
Telephone: +44 1223 432360 (Help Desk); +44 1223 420066 (Switchboard)
800 Line: 800-473-9234
Fax: +44 1223 423429
E-Mail: marketing@rsc.org


Terms and Conditions [top]

For Dialog's Redistribution and Archive Policy, enter HELP ERA online. The following terms and conditions also apply.

These databases are copyrighted by The Royal Society of Chemistry (RSC). These databases may not be copied in entirety. Portions of the databases may not be copied such as to have the effect of avoiding use charges for the databases. Except as expressly stated in Dialog Redistribution and Archive Policy, copies may not be offered for resale. RSC shall use its best endeavours to ensure that the information contained in the databases is accurate and up-to-date, but RSC accepts no liability for omissions or errors therein or their consequences.


Dialog Standard Terms & Conditions apply.


SAMPLE RECORD [top]

    DIALOG(R)File 307:DOSE 
    (c) 1997 Royal Society of Chemistry.  All rts. reserv. 
     
  AA=  00000810                                  Record Id: 1359 
  /CN,CN=,/NA,NA=  SUBSTANCE NAME: styrene oxide 
  RN=  CAS REGISTRY  NUMBER 96-09-3 
  /NA,NA=,/SY,SY=  SYNONYMS: phenyloxirane; (epoxyethyl)benzene; 1,2-epoxy- 
      1-phenylethane; epoxystyrene; phenethylene oxide; styryl 
      oxide; phenyl oxirane 
  US=, /US  USES: In manufacture of styrene glycol and derivatives. In 
      manufacture of epoxy resins, beta-phenethyl alcohol, 
      polyols and  agrochemicals. In treatment of textiles and 
      fibres. 
  /OC, OC=   OCCURS: Tentatively identifed in US air samples (1,2). In effluent from 
      latex and chemical plants (3). 
  /PP  PHYSICAL PROPERTIES: 
  MW=    MOLECULAR WEIGHT: 120.15 
  MF=, EC=, /EC,    MOLECULAR FORMULA: C8H8O 
  ME=, NC=, NE=   
  MP=, MT=    MELTING POINT: -35.6 Deg C 
  BP=, BT=    BOILING POINT: 194 Deg C 
  VP=, VT=    VAPOR PRESSURE: v.p. 0.3 mmHg at 20 Deg C ; v.den. 4.1 
  DN=, DT=    DENSITY: d(16)4 1.0523 
  PI=, PT=    PARTITION COEFFICIENT: log Pow 1.61 
  SL=    SOLUBILITY WATER (NUMERIC): 0.3% 
  SL=    SOLUBILITY OTHER SOLVENTS: ethanol, diethyl ether, 
      benzene, acetone, carbon tetrachloride, heptane, 
      methanol 
  FP=, FT=    FLASH POINT: 79 Deg C (open cup) 
     
  /RG  REGULATORY: 
      REGULATORY NUMBERS: 
  NI=, RR=      NIOSH Number: CZ 9625000 
  EI=      EINECS/ELINCS No.: 202-476-7 
        Supply Classification: toxic 
        Risk Phrases: May cause cancer -Harmful in contact 
        with skin -Irritating to the eyes   (R45, R21, R36) 
        Safety Phrases: Restricted to professional users 
        -Avoid exposure -obtain special instruction before 
        use -In case of accident or if you feel unwell, seek 
        medical advice immediately (show label where possible) 
        (S53, S45) 
     
  /TO  TOXICITY: 
      MAMMALIAN AND AVIAN TOXICITY: 
        ACUTE TOXICITY: LD50 oral mouse, rat 1500, 2000 mg 
          kg(-1), respectively (5,6). LCLo (4 hr) inhalation 
          rat  500 ppm (7). LD50 dermal rabbit 1060 mg kg(-1) 
          (7). LD50 intraperitoneal rat 460 mg kg(-1) (8). 
        SUB-CHRONIC TOXICITY: Mortality was high in rats 
          inhaling 97 or 300 ppm 7 hr day(-1) for 3 wk 
          pregestational period and on gestation days 1-19 
          (9,10). 
      CARCINOGENICITY AND CHRONIC EFFECTS: 
         No adequate evidence for carcinogenicity in humans, 
          sufficient evidence for carcinogenicity in animals, 
          IARC classification group 2A (11).  BDIV and 
          Sprague-Dawley rats developed significantly increased 
          incidence of forestomach tumours following  oral 
          administration (12,13). In skin painting studies mice 
          showed no increased incidence of skin tumours (14). 
        GENOTOXICITY: Salmonella typhimurium TA100, TA1535 
          without metabolic activation positive (31-33). 
          Salmonella typhimurium TA98, TA1537, TA1538 with and 
          without metabolic activation negative (31-33). 
          Saccharomyces cerevisiae mitotic gene conversion 
          positive (34). Drosophila melanogaster sex-linked 
          recessive lethal mutations positive (35).  In vitro 
          rat hepatocytes DNA single-strand breaks positive 
                        (...) 
  /TO  TERATOGENICITY AND REPRODUCTIVE EFFECTS: Inhalation 
        exposure during gestation to 15-100 ppm reduced 
        fecundity, foetal weight and length in rats and 
        rabbits and   gave  rise to ossification defects in 
        rats (9,15,16). Reduced embryonic viability and 
        malformations reported when administered to hens 
        eggs (17,18). 
  /TO  METABOLISM AND TOXICOKINETICS: Detected in the venous 
        blood of workers exposed to styrene (3). Following 
        intraperitoneal injection of styrene to   mice the 
        highest concentrations were found in the kidneys, 
        subcutaneous adipose tissue and blood 1-5 hr after 
        administration   (19,20).   Hydrolysed microsomal 
        epoxide hydrolase from the liver, kidneys, lungs, 
        intestine, and skin of several mammalian species to 
        styrene  glycol (21). Other metabolic products include 
        mandelic acid and glutathione conjugates (22,23). 
                           (...) 
  /TO  ADVERSE EFFECTS: 
      IRRITANCY: Dermal rabbit (24 hr) 10 mg caused well 
        defined erythema and slight oedema (open to the air) 
        (5). Skin irritant in humans  (28). 
      SENSITIZATION: Guinea pig skin sensitised by intradermal 
        injection (29). Caused eye and skin irritation and 
        skin sensitisation in   humans  (30). 
      OTHER ADVERSE EFFECTS TO MAN: Inhalation may cause 
        fatigue, headache, weakness, peripheral neuropathy, 
        unsteady gait and central nervous system depression 
        (28). 
      OTHER ADVERSE EFFECTS: Activities of liver mixed function 
        oxidases and cytochrome P450 content decreased 
        following single intraperitoneal dose of 375 mg kg(-1) 
        body weight to rat (40). Concentrations of 50 and 200 
        mg kg(-1) body weight  in rat decreased liver 
        glutathione content (25). 
  /DM  ENVIRONMENTAL FATE: 
      ABIOTIC REMOVAL: Waste water treatment: activated carbon 
        adsorbability, 0.19 g g(-1) carbon; 95.3% reduction, 
        influent 1000 mg l(-1), effluent 47 mg l(-1) (4). 
  /TO  OTHER COMMENTS:Genotoxicity reviewed (41,42). Metabolism 
      and pharmacokinetics reviewed (27). Experimental 
      toxicology, human   health  effects, physico-chemical 
      properties and environmental effects reviewed (43). 
      Autoignition temperature 498 Deg C. 
  RF=  REFERENCES: 
      1. Pellizzari, E. D. et al Anal. Chem. 1976, 48, 
          803-807. 
      2. Sawicki, E. Environmental Pollution and Carcinogenic 
          Risks (INSERM Symposium Series Vol. 52IRC Scientific 
          Publications   No.  13) 1976, 315-316, Institut 
          National de la Saute et de la Recherche Medicale, 
          Paris, IARC, Lyon. 
                        (...) 
      43. ECETOC Technical Report No. 30(5) 1994, European 
          Chemical Industry Ecology and Toxicology Centre, 
          B-1160 Brussels 
  DP=, /DP  DATA PRESENT: Uses; Melting Point; Boiling Point; Vapor 
      Pressure; Density; Partition Coefficient; Solubility; 
      Solubility-Organic; Flash Point; Regulatory; Toxicity; 
      Adverse Effects; Reproductive Effects; Metabolism; 
      Environmental Fate 
  RD=, PD=, PY=  RECORD DATE:  27 Mar 1997 


BASIC INDEX [top]

SEARCH
SUFFIX
DISPLAY
CODE
FIELD NAME
INDEXING
SELECT EXAMPLES
None None All Basic Index Fields Word S LYMPHOMA AND BONE(W)MARROW
/CN CN Main Substance Name1,2,3 Segment
& Word & Phrase
S METHYL/CN
S STYRENE(W)OXIDE/CN
S STYRENE OXIDE/CN
/DE DE Chemical Name1,2,3,4 Segment
& Word & Phrase
S PHENYL(W)ETHANE/NA
S EPOXY(1W)PHENYLETHANE/NA
S 1,2-EPOXY-1-PHENYLETHANE/NA
/DM DM Environmental Fate and Bioaccumulation5 Word S EFFLUENT/DM
S (BOD OR THOD)/DM
/DP DP Data Present1,6 Word S FLASH(W)POINT/DP
/EC MF Element Count1 Word S C8(S)O1/EC
/NA NA Chemical Name1,2,3,4 Segment
& Word & Phrase
S PHENYL(W)ETHANE/NA
S EPOXY(1W)PHENYLETHANE/NA
S 1,2-EPOXY-1-PHENYLETHANE/NA
/OC OC Occurrence Word S AIR(W)SAMPLE?/OC
/PP PP Physical Properties Word S LOG(W)POW/PP
/RG RG Regulatory Information Word S NIOSH(W)NUMBER/RG
/SY SY Synonyms1,2,3 Segment
& Word & Phrase
S ETHYLENE/SY
S PHENETHYLENE(W)OXIDE/SY
S PHENETHYLENE OXIDE/SY
/TO TO Toxicity7 Word S (LD50(5W)RAT)/TO
/US US Uses1 Word S (AGROCHEMICALS OR RESINS)/US

1 Searchable in the Basic Index and in the Additional Indexes.

2 All chemical names are searchable as /NA, /DE, or NA=.

3 Chemical names are indexed as complete phrases, individual words, and chemically significant segments of words. Use /FW to restrict rerieval to the complete term, e.g., S ETHANE/FW to only select ethane as a single word rather than as a segment of a larger chemical term, such as trichloroethane.

4 Also /DF.

5 Also searchable as /TO; also displays with TO.

6 Possible entries for Data Present are: Adverse Effects; Boiling Point; Density; Environment Fate; Flash Point; Melting Point; Metabolism; Partition Coefficient; Regulatory; Reproductive Effects; Solubility; Toxicity; Uses; Vapor Pressure.

7 Toxicity field includes Adverse Effects, Reproductive Effects, and Metabolism Effects.


ADDITIONAL INDEXES [top]

SEARCH
PREFIX
DISPLAY
CODE
FIELD NAME
INDEXING
SELECT EXAMPLES
AA= AA Record Identification Number Phrase S AA=1359
None AE Adverse Effects7
None AN DIALOG Accession Number
None AZ DIALOG Accession Number
BP= BP Boiling Point (Celsius)8,10 Numeric S BP=190:200
BT= BT Boiling Point Text Word S BT=(194 AND DEG)
CN= CN Main Substance Name1,2 Phrase S CN=STYRENE OXIDE
DN= DN Density (Specific Gravity)8,10 Numeric S DN=>1.0
DP= DP Data Present1,6 Phrase S DP=PARTITION COEFFICIENT
DT= DT Density Text Word S DT=(1(W)0523)
EC= MF Element Count1 Phrase S EC=(C0008(S)O0001)
EI= EI EINECS/ELINCS Number Phrase S EI=202-476-7
FP= FP Flash Point (Celsius)8,10 Numeric S FP=75:80
FT= FT Flash Point Text Word S FT=(OPEN(W)CUP)
ME= MF Molecular Elements Present Phrase S ME=CHO
MF= MF Molecular Formula Phrase S MF=C8H8O
MP= MP Melting Point (Celsius)8,10 Numeric S MP=-35.6
MT= MT Melting Point Text Word S MT=(35(W)6(W)DEG (W)C)
MW= MW Molecular Weight8 Numeric S MW=120.15
NA= NA Chemical Name1,2 Phrase S NA=PHENYL OXIRANE
NC= MF Number of Components Phrase S NC=01
NE= MF Number of Elements Phrase S NE=03
NI= NI NIOSH Number Phrase S NI= CZ 9625000
OC= OC Occurrence Word S OC=LATEX
PD= PD Record Date9 Phrase S PD=970327
PI= PI Partition Coefficient8,10 Numeric S PI=1.61
PT= PT Partition Coefficient Text Word S PT=(LOG(W)POW(W)1(W)61)
PY= PY Publication Year Phrase S PY=1997
RD= RD Record Date9 Phrase S RD=27 Mar 1997
RF= RF References Word S RF=(EUROPEAN(W)CHEMICAL(W)IND?)
RN= RN CAS(R) Registry Number Phrase S RN=96-09-3
RR= RR RTECS Number Phrase S RR=CZ9625000
SL= SL Solubility Word S SL=(ETHANOL AND ACETONE)
S SL=(0(W)3)
SY= SY Synonyms1,2 Phrase S SY=1,2-EPOXY-1-PHENYLETHANE
UD= None Update Phrase S UD=9999
UN= UN UN Number Phrase S UN=1114
US= US Uses1 Word S US=(TEXTILES OR FIBRES)
VP= VP Vapor Pressure (mmHg)8,10 Numeric S VP=0.3
VT= VT Vapor Pressure Text Word S VT=(0(W)3(W)MMHG AND V(W)DEN)

8 Numeric values can be entered in several different ways: directly as a number, e.g. S BP=100.0; or in exponential notation, e.g. S BP=1E2. Letter abbreviations are also available: K for thousand; M for million, B for billion, e.g. S BP=0.5K:1.0K. To search a range of values, use a colon between starting and ending values, e.g. S BP=78:79, or use numeric operators (>, <, >=, and <=) e.g. S 78<=BP<=79.

9 Record Date, RD=, and Publication Date, PD=, contain the same information, formatted differently.

10 KWIC does not work on the following fields in this database: BP, DN, FP, MP, PI, and VP.


LIMIT [top]

Sets and terms may be limited by Basic Index suffixes, i.e., /CN, /DE, /DM, /DP, /EC, /NA, /PP, /RG, /SY, /TO, /US (e.g., SELECT S3/TO/ALL).


SORT [top]

SORTABLE FIELDS EXAMPLES
CN, MF, PD, RN, SY SORT S4/ALL/RN
PRINT S7/9/ALL/CN


RANK [top]

RANK FIELDS EXAMPLES
All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. RANK BP
RANK CN S4


MAP [top]

MAP FIELDS EXAMPLES
NA, RN, SY MAP SYRN TEMP S2


USER-DEFINED FORMAT OPTIONS [top]

User-defined formats may be specified using the display codes indicated in the Search Options tables. TYPE S4/NA,RN,TO/1-5


PREDEFINED FORMAT OPTIONS [top]

NO.
DIALOGWEB
FORMAT
RECORD CONTENT
1 -- DIALOG Accession Number
2 -- Chemical Names, CAS Registry Number, Molecular Weight, Molecular Formula, Toxicity, Environmental Effect, and Data Present11
3 Medium Chemical Names, CAS Registry Number, Physical Properties, and Data Present11
4 -- Full Record with Tagged Fields
5 Long Full Record
6 -- Chemical Names
7 -- Chemical Names, CAS Registry Number, Molecular Weight, Molecular Formula, Regulations, and Data Present11
8 Short Chemical Names and Data Present
9 Full Full Record
K -- KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats

11 In the place of a format number, a format name can also be specified to indicate the format, e.g., TYPE S1/TOX/ALL. The Named Formates available are: TOX, PROP, and REG.


DIRECT RECORD ACCESS [top]

FIELD NAME EXAMPLES
If the accession number of a specific record is known, it can be used to display the record directly. TYPE 00199665
DISPLAY 0002789/CO,PC
PRINT 0000987/5


Rates [top]

Rates For File: Dictionary of Substances and Their Effects (DOSE)[307]
Cost per DialUnit:                 $2.24
Cost per minute:                   $0.81
Rank Elements                      $0.00

Format    Types   Prints
     1    $0.00    $0.00
     2    $9.73    $9.73
     3    $9.73    $9.73
     4   $15.56   $15.56
     5   $15.56   $15.56
     6    $1.95    $1.95
     7   $15.56   $15.56
     8   $15.56   $15.56
     9   $15.56   $15.56
KWIC95    $1.30       NA
KWIC96    $1.24       NA
[top]



All contents Copyright © Thomson Reuters. All rights reserved.
If you have any questions about, problems with, or corrections for our Web site,
please contact Customer Service for assistance.