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304
The Merck Index OnlineSM

Last Loaded on Web: Tuesday, October 01, 2013

Last Update To Bluesheet: July 1, 2009

Bluesheet Contents     PDF version

File Description Print Counterparts Special Features Sample Record Sort Rates
Subject Coverage Dialog File Data DIALINDEX/OneSearch Categories Basic Index Rank
Sources Document Types Indexed Contact Additional Indexes Map
Tips Geographic Coverage Terms and Conditions Limit Predefined Format Options


File Description [top]

The Merck Index OnlineSM is the online version of the monographs in the printed 14th Edition of The Merck Index (a U.S. publication, Whitehouse Station, N.J., USA), an internationally recognized, one-volume encyclopedia of chemicals, drugs, and biologicals. Each monograph in the encyclopedia (each record in the database) discusses a single chemical entity or a small group of very closely-related compounds. Updates contain material not yet available in print.

Records contain:

  • chemical, common, generic and systematic names (including CAS® names)
  • trademarks and associated companies
  • CAS® Registry Numbers
  • molecular formulae, weights and percentage composition
  • capsule statements identifying compound classes and scientific significance
  • chemical, biomedical and patent literature references
  • physical and toxicity data
  • therapeutic and commercial uses
  • caution and hazard information

The 14th Edition also contains "retired" records from earlier editions of The Merck Index which still contain valuable information but are no longer being updated with new information



Tips [top]

USE FILE 304

to find concise descriptions of specific chemicals, drugs, or biologicals.

USE NA= or /NA

to locate a substance record by its systematic name, synonym, or brand name, particularly when you don't know which kind of name you have.

     EXPAND NA=ENALAPRIL      SELECT PHENYLPROPYL/NA

USE MAP RN

to create a SearchSave of the CAS®Registry Numbers for further searching in other chemistry files.

USE /ACTIVE

to restrict a search in file 304 to 14th Edition records.

SELECT CO=AVENTIS/ACTIVE


Subject Coverage [top]

  • human and veterinary drugs
  • biotech drugs and monoclonal antibodies
  • substances used for medical imaging
  • biologicals and natural products
  • plants and herbal medicines
  • agricultural chemicals (including pesticides and herbicides)
  • organic and inorganic chemicals used in commerce and research
  • laboratory reagents and catalysts
  • dyes, colors and indicators
  • environmentally significant substances


Sources [top]

Records contain active citations to and information from approximately 800 international chemical, biomedical,and clinical journals; patents issued by 30 countries; books; proceedings; and other standard reference works. Retired citations which are also included but are not longer updated.



Print Counterparts [top]

  • The Merck Index


Dialog File Data [top]

Dates Covered: Late 19th Century to the present
File Size: 11338 records as of July 2009
Update Frequency: Semi-Annual


Document Types Indexed [top]

  • Chemical Substances


Geographic Coverage [top]

  • International


Geographic Restrictions [top]

  • None


Special Features [top]

  • ERA Available
  • Graduate Education Program
  • KWIC and HILIGHT Available
  • MAP Available


DialIndex/OneSearch Categories [top]

ACRONYM CATEGORY NAME
BRANDNMS Brand Names
CASREGNO CAS(R) Registry Numbers-Chemical and Medical Files
CHEMPROP Chemical Properties
CHEMSUBS Chemical Substances
DRUGDIR Drug Directories
RNCHEM CAS(R) Registry Numbers - Chemistry Files
RNLOOKUP CAS(R) Registry Number Lookup
RNMED CAS(R) Registry Numbers - Medical Files


Contact [top]

The Merck Index Online is produced by Merck & Co., Inc., Whitehouse Station, NJ, USA. Questions concerning file content should be directed to:

Merck & Co., Inc.
Box 2000
Rahway, NJ 07065-0900

Telephone: 732-594-7143
Fax: 732-594-1187


Terms and Conditions [top]

The Merck Index Online is a registered service mark of Merck & Co., Inc., Whitehouse Station, N.J., USA

The Merck Index OnlineSM is a service mark of Merck & Co., Inc., Whitehouse Station, N.J., USA. The Merck Index copyright by Merck & Co. Inc., 2009. All rights reserved. Merck & Co. Inc. cannot be responsible for errors in publication or for any consequences arising from use of the information contained in The Merck Index Online. Reference to original sources is encouraged.


Dialog Standard Terms & Conditions apply.


SAMPLE RECORD [top]

    File 304:THE MERCK INDEX ONLINE(SM) 2009/S1 
    (c) 2009 Merck & Co,Inc, All rts rsvd 
     
  AN=,/MN,MN=    08428     Monograph Name: Selegiline 
  RN=  CAS REGISTRY NUMBER: 14611-51-9 
  MF=,MW=  MOLECULAR FORMULA: C13H17N   MOLECULAR WEIGHT: 187.28 
    MOLECULAR COMPOSITION: C 83.37%, H 9.15%, N 7.48% 
  /CN,CN=,/NA,NA=,/DE  C.A. CHEMICAL NAME(s): (alphaR)-N,alpha-Dimethyl-N-2-propyl-1-ylbenzeneetha 
      namine 
    SYNONYMS: 
  /SY,SY=,/NA,NA=,/DE   L-(-)-N,alpha-dimethyl-N-2-propynylphenethylamine ; L-N-(2-phenylisopropyl 
     )-N-methylprop-2-ynylamine ; (-)-deprenil ; L-deprenyl 
    BRAND NAME (and COMPANY): 
  /TN,TN=,/CO,CO=   Emsam  (Somerset) 
    LITERATURE REFERENCES: 
  /SO,SO=   Monoamine oxidase-B inhibitor related structurally to pargyline, q.v. 
     Prepn of racemate: FR 1368136; GB 1031425 ( 1964, 1966 both to Chinoin ); 
     of (-)-form: NL 6605956; GB 1153578 ( 1966, 1969 both to Chinoin ); J. S. 
     Fowler, J. Org. Chem. 42, 2637 ( 1977 ) 
     (http://dx.doi.org/10.1021/jo00435a026)(http://www.ncbi.nlm.nih.gov/pubmed 
     /874623). Pharmacology and toxicology of racemate: J. Knoll et al., Arch. 
     Int. Pharmacodyn. 155, 154 ( 1965 ) 
     (http://www.ncbi.nlm.nih.gov/pubmed/4378644); of isomers: K. Magyar et 
     al., Acta Physiol. Acad. Sci. Hung. 32, 377 ( 1967 ) 
     (http://www.ncbi.nlm.nih.gov/pubmed/5595908). Review of pharmacology: E. 
     H. Heinonen, R. Lammintausta, Acta Neurol. Scand. Suppl. 136, 44 -59 ( 
     1991 ) (http://www.ncbi.nlm.nih.gov/pubmed/1686954); of efficacy in 
     Parkinson's disease: D. W. Robin, Am. J. Med. Sci. 302, 392 -395 ( 1991 ) 
     (http://dx.doi.org/10.1097/00000441-199112000-00014)(http://www.ncbi.nlm.n 
     ih.gov/pubmed/1772127); K. L. Poston, C. Waters, Expert Opin. 
     Pharmacother. 8, 2615 -2624 ( 2007 ) 
     (http://dx.doi.org/10.1517/14656566.8.15.2615)(http://www.ncbi.nlm.nih.gov 
     /pubmed/17931095). Review of veterinary use in canine cognitive 
     dysfunction: W. W. Ruehl, B. L. Hart in Psychopharmacology of Animal 
     Behavior Disorders, N. H. Dodman, L. Shuster, Eds. (Blackwell Sci., 
     Malden, Mass., 1998) pp 283-304. Review of transdermal selegiline in major 
     depressive disorder: D. S. Robinson, J. D. Amsterdam, J. Affect. Disord. 
     105, 15 -23 ( 2008 ) 
     (http://dx.doi.org/10.1016/j.jad.2007.04.024)(http://www.ncbi.nlm.nih.gov/ 
     pubmed/17568687). 
    PATENT INFORMATION: 
  PN=   FR 1368136; GB 1031425; NL 6605956; GB 1153578 
    PHYSICAL DATA: 
  /PP,PP=   Oil, bp0.8 92-93. nD20 1.5180. 
    PHYSICAL DATA: 
  BT=,BP=   BOILING POINT: bp0.8 92-93 
  RE=,RI=   REFRACTIVE INDEX: nD20 1.5180 
    DERIVATIVE INFORMATION: 
  ? /SY,SY=,/NA,NA=,/DE   SUBSTANCE: Selegiline Hydrochloride 
  RN=     DERIVATIVE CAS RN: 14611-52-0 
  MF=     DERIVATIVE MOLECULAR FORMULA: C13H17N.HCl 
  MW=     MOLECULAR WEIGHT: 223.74 
       MOLECULAR COMPOSITION: C 69.79%, H 8.11%, N 6.26%, Cl 15.85% 
  /TN,TN=,/CO,CO=     DERIVATIVE BRAND NAME (COMPANY): Anipryl (Deprenyl); Antiparkin (Viatris); 
        Amindan (Desitin); Carbex (Endo); Deprenyl (Orion); Egibren (Chiesi); 
        Eldepryl (Somerset); Jumex (Chiesi); Movergan (Orion); Otrasel 
        (Cephalon); Plurimen (Viatris); Seledat (Master); Selegam (Hexal); 
        Selepark (Betapharm); Selgimed (Hennig); Xilopar (Cephalon); Zelapar 
        (Valeant) 
  /PP,PP=     DERIVATIVE PHYSICAL DATA: Crystals, mp 141-142. (alpha)25/D: -10.8 (c = 
        6.48 in water). Freely sol in water, chloroform, methanol. LD50 in rats 
        ( mg/kg ): 81 i.v., 280 s.c. (Magyar). 
  MP=,MT=     MELTING POINT: 141-142 
  OP=,OT=     OPTICAL ROTATION: (alpha)25/D: -10.8 (c = 6.48 in water) 
  LD=     LD50: LD50 in rats ( mg/kg ): 81 i.v., 280 s.c. (Magyar) 
  /SY,SY=,/NA,NA=,/DE   SUBSTANCE: Selegiline (+/-)-Form 
  RN=     DERIVATIVE CAS RN: 2323-36-6; 
  /SY,SY=,/NA,NA=,/DE     DERIVATIVE SYNONYMS: Deprenyl ; phenylisopropyl-N-methylpropinylamine 
  /PP,PP=     DERIVATIVE PHYSICAL DATA:  Oil, bp5 104-110. nD20 1.5229. 
  BP=,BT=     BOILING POINT:  bp5 104-110 
  RE=,RI=     REFRACTIVE INDEX:  nD20 1.5229 
  /SY,SY=,/NA,NA=,/DE   SUBSTANCE: Selegiline (+/-)-Form hydrochloride 
  RN=     DERIVATIVE CAS RN: 2079-54-1; 
  /SY,SY=,/NA,NA=,/DE     DERIVATIVE DRUG CODES: E-250 
  /PP,PP=     DERIVATIVE PHYSICAL DATA:  Crystals from ethanol + ether, mp 131-131.5. 
        LD50 in rats ( mg/kg ): 63 i.v., 126 s.c., 385 orally (Knoll). 
  MP=,MT=     MELTING POINT:  131-131.5 
  LD=     LD50:  LD50 in rats ( mg/kg ): 63 i.v., 126 s.c., 385 orally (Knoll) 
  /Tc,RC=  THERAPEUTIC CATEGORY: Antiparkinsonian; antidepressent. 
  /TC,TV=  THERAPEUTIC CATEGORY VET: In treatment of canine cognitive dysfunction 
     syndrome. 
  /KS,KW=  KEYWORDS: Antiparkinsonian; Monoamine Oxidase Inhibitor; Antidepressant; 
     Others 
  /DP.RP=  REFERENCE KEYS PRESENT: Pharmacology; Prepn; Review; Toxicology; Use; 
     Patent number 
  /DP,DP=  DATA KEYS PRESENT: Boiling point; Refractive Index; Patent Number; 
     Molecular Weight; Therapeutic Category; Therapeutic Category Vet 
  /DP,DP=  DATA KEYS PRESENT IN DERIVATIVE: Melting point; Boiling point; Optical 
     Rotation; Refractive Index; Lethal Dose 
     


BASIC INDEX [top]

SEARCH
SUFFIX
DISPLAY
CODE
FIELD NAME
INDEXING
SELECT EXAMPLES
None None All Basic Index Fields Word S ALPHA(W)DIMETHYL
S METHYL
/CN CN CA Chemical Name1,2 Segment
& Word & Phrase
S PROPYL/CN
S PHENYLPROPYL(1W)ALANYL/CN
S "S)-1-(N-(1-(ETHOXYCARBONYL)-3"?/CN
/CO CO Company Name1 Word S MERCK/CO
/DE DE Chemical Name Segment
& Word & Phrase
S PHENYL/DE
S SELEGILINE(W)HYDROCHLORIDE/DE
S SELEGILINE HYDROCHLORIDE/DE
/DP DP Data Present1,3 Word S MELTING(W)POINT
/EC MF Element Count1,2 Phrase S (C13(S)H17)/EC
/KW KW Keywords1 Word S ANTIPARKINSONIAN/KW
/MN MN Monograph Name1,2 Segment
& Word & Phrase
S CHLORIDE/MN
S SELEGILINE/MN
S SELEGILINE HYDROCHLORIDE/MN
/NA NA Chemical Name1,2 Segment
& Word & Phrase
S PHENYL/NA
S L(W)DEPRENYL/NA
S ENALAPRIL MALEATE/NA
/NT NT Notes, Cautions, and Uses Word S MORDANT(S)CATALYST/NT
/PP PP Physical Property Information3 Word S WHITE(1W)POWDER/PP
/SO SO Sources/References4,5 Word S J(W)AFFECT?(W)DISORD?/SO
S U(W)S(W)PAT?/SO
/SY SY Synonyms Including Brand Names and Drug Codes1,2 Segment
& Word & Phrase
S ANITPARKIN/SY,DERIV
S CO(W)RENITEC/SY
S CO-RENITEC/SY
/TC TC Therapeutic Category6 Word S ANTIDEPRESSANT/TC
/TN TN Brand Name1,2 Segment
& Word & Phrase
S EMSAM/TN
S CARBEX/TN,DERIV
S CO-RENITEC/TN

1 Searchable in the Basic Index and in the Additional Indexes. Any numeric values are searchable in the Basic Index using the (W) operator, e.g. S 143(W)144(W)5/PP

2 All chemical names are indexed as complete phrases, individual words, and chemically significant segments of words. Use /FW to restrict retrieval to the complete term, e.g., S ETHANE/FW to only select ethane as a single word rather than as a segment of a larger chemical term, such as trichloroethane.

3 Searchable as /DP in the Basic Index and using DP= or RP= in the Additional Indexes.

4 Includes Monograph Name (/MN, MN=), C.A. Names (/CN, CN=), Brand Names (/TN, TN=), Derivative Names (/DERIV), Drug Codes (/SY, SY=), and Synonyms (/SY, SY=).

5 Recent records include the URLs which can be used to locate the original article based on the DOI (digital object identifier) or the PUBMED identifier. Although not provided as hot links, the URL can be pasted into any internet browse by copying the URL string contained in the record..

6 Searchable using /TC in the Basic Index and using TC= or TV= in the Additional Indexes.


ADDITIONAL INDEXES [top]

SEARCH
PREFIX
DISPLAY
CODE
FIELD NAME
INDEXING
SELECT EXAMPLES
AN= AN DIALOG Accession Number Phrase S AN=08428
AN= AN THE MERCK INDEX Monograph Number Phrase S AN=08428
S AN=1310215/RETIRED
BP= BP Boiling Point (Celsius)1,7 Numeric S BP=92.000
BT= BP Boiling Point Text1 Word S BT=BP5
CN= CN C.A. Chemical Name1 Phrase S CN=S)-1-(N-(1-(ETHOXYCARBONYL?
CO= CO Company Name1 Phrase S CO=MERCK & CO?
DN= DN Relative Density1,7 Numeric S DN=1.0000
DP= DP Data Present1,3 Phrase S DP=(BOILING POINT AND MELTING POINT)
DT= DN Density Text1 Word S DT=SUPERCOOLED AND DN=1.0
EC= MF Element Count1 Phrase S EC=(C0013 AND H0017)
S EC=N0001:N0005
FF= FP Flash Point (Fahrenheit)1,7 Numeric S FF=84.2
FP= FP Flash Point (Celsius)1,7 Numeric S FP=29
FT= FP Flash Point Text1 Word S FT=(CLOSED(W)CUP)
KW= KW Keywords1 Word S KW=MONOAMINE(W)OXIDASE)
LD= LD Lethal Dose (LD50)1 Word S LD=RATS
ME= None Molecular Elements Phrase S ME=CHN
MF= MF Molecular Formula Phrase S MF=C13H17N.HCL
MN= MN Monograph Name1 Phrase S MN=SELEGILINE
MP= MP Melting Point1,7 Numeric S MP=141.000
MT= MP Melting Point Text1 Word S MT=DEG
MW= MW Molecular Weight7 Numeric S MW=187.26
NA= NA Chemical Name1,4 Phrase S NA=ENALAPRIL
OP= OP Optical Rotation1,7 Numeric S OP=10.1:10.9
OT= OP Optical Rotation Text1 Word S OT=(ALPHA(S)22(S)546)
PN= PN Patent Number1 Phrase S PN=gb 1031425
PP= PP Physical Property Information1 Word S PP=(OFF(W)WHITE AND POWDER)
RE= RE Refractive Index1,7 Numeric S RE=1.518:1.519
RI= RE Refractive Index Text1 Word S RI=(ND(W)20)
RN= RN CAS(R) Registry Number Phrase S RN=14611-51-9
S RN=14611-51-9/MAIN
S RN=2323-36-6/DERIV
RP= RP References Present3 Phrase S RP=PHARMACOLOGY
SO= SO Bibliographic Sources4,5 Word S SO=(FERGUSON(S)J(1W)CLIN(W)PHARMACOL?)
SY= SY Synonyms Including Brand Names and Drug Codes1 Word
& Phrase
S SY=INNOVACE
S SY="1-(N-((S)-1-CARBOXY-3-PHENYLPROPYL"?
TC= TC Therapeutic Category1,6 Word S TC=ANTIPARKINSONIAN
TN= TN Brand Name1 Phrase S TN=EGIBREN
TV= TV Therapeutic Category (Veterinary)1 Word S TV=(COGNITIVE(W)DISFUNCTION)
UD= None Update Phrase S UD=9999
US= US Uses1 Word S US=(MORDANT(S)LEATHER)
UT= UV Ultraviolet Maximum Text1 Word S UT=ALCOHOL AND UV=235
UV= UV Ultraviolet Maximum1,7 Numeric S UV=260:265
DISPLAY ONLY
None B1 Boiling Point (Derivative)
None C1 CA Chemical Name (Derivative)
None C2 Company Name (Derivative)
None D1 Data Present (Derivative)
None D2 Relative Density (Derivative)
None FL Flash Point (Derivative)
None L1 Lethal Dose (LD50) (Derivative)
None M1 Molecular Composition(Derivative)
None M2 Molecular Formula (Derivative)
None M3 Melting Point (Derivative)
None M4 Molecular Weight (Derivative)
None MC Molecular Composition
None N1 Chemical Names (Derivative)
None N2 Chemical Names, Additional (Derivative)
None O1 Optical Rotation (Derivative)
None P1 Physical Property Information (Derivative)
None R1 Refractive Index (Derivative)
None R2 CAS Registry Number (Derivative)
None SB Bibliographic Sources (Derivative)
None SM Synonyms (Derivative)
None ST Record Status for Retired Records
None T1 Brand Name (Derivative)
None UM Ultraviolet Maximum (Derivative)

7 Numeric values can be entered in several different ways: directly as a number, e.g. S BP=100:0; or in exponential notation, e.g. S BP=1E2. Letter abbreviations are also available: K for thousand; M for million, B for billion, e.g. S BP=0.5K:1.0K. To search a range of values, use a colon between starting and ending value, e.g. S BP=78:79 OR use numeric operators (>, <, >=, and <=), e.g. S 78<=BP<=79.


LIMIT [top]

SUFFIX FIELD NAME EXAMPLES
/ACTIVE Active Records from the 14th Edition S S2/ACTIVE
/DERIV Information relating to the derivative data mentioned in the monograph S S2/DERIV
/MAIN Information relating to the main monograph substance data S S1/MAIN
/RETIRED Records from Earlier Editions which are not being Actively Updated S S1/RETIRED


SORT [top]

SORTABLE FIELDS EXAMPLES
MF, MN, RN, TC SORT S2/ALL/MN
PRINT S2/5/1-20/TC


RANK [top]

RANK FIELDS EXAMPLES
All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. RANK NA
RANK BP S4


MAP [top]

MAP FIELDS EXAMPLES
MN, NA, PN, RN MAP RN TEMP S4
MAP SYRN TEMP S3


USER-DEFINED FORMAT OPTIONS [top]

Display codes listed in the Search Options tables can be used to customize output. TYPE S3/MN,MF,MP,BP/1-10


PREDEFINED FORMAT OPTIONS [top]

NO.
DIALOGWEB
FORMAT
RECORD CONTENT
1 -- DIALOG Accession Number
2 -- Full Record, except Literature References and Physical Data
3 Medium Full Record, except Physical Data
4 -- Full Record
5 -- Full Record
6 Free DIALOG Accession Number/Monograph Number, Monograph Name, CAS Registry Number, and Molecular Formula
7 Long Full Record, except Literature References
8 Short DIALOG Accession Number/Monograph Number, Monograph Name, CAS Registry Number, Molecular Formula, Therapeutic Categories, References Present, Data Present
9 Full Full Record
K -- KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats


DIRECT RECORD ACCESS [top]

FIELD NAME EXAMPLES
If the accession number of a specific record is known, it can be used to display the record directly. TYPE 03521/5
DISPLAY 03521/MN,MF,MP
PRINT 03521/9


Rates [top]

Rates For File: The Merck Index OnlineSM[304]
Cost per DialUnit:                 $1.30
Cost per minute:                   $0.58
Rank Elements                      $0.00

Format    Types   Prints
     1    $0.00    $0.00
     2    $3.00    $3.00
     3    $3.00    $3.00
     4    $3.00    $3.00
     5    $3.00    $3.00
     6    $0.00    $0.00
     7    $3.00    $3.00
     8    $0.00    $0.00
     9    $3.00    $3.00
KWIC95    $0.40       NA
KWIC96    $0.40       NA

REDIST/COPY Multiplier Table:

      Range      Multiplier
        1-2       1.00
       3-25       1.50
     26-100       3.00
    101-200       4.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

ARCHIVE Multiplier Table:

      Range      Multiplier
       1-25       1.50
     26-200       3.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00
[top]



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