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Last Loaded on Web: Wednesday, May 01, 2013
Index Chemicus focuses on current awareness of new compounds and reports with over 200,000 new compounds and synthetic intermediates added each year, with coverage of over 2.4 million structures published in the literature since 1993. Covering the world's leading organic chemistry journals, Index Chemicus is a text- and substructure-searchable database. It serves as both a compound database and a current awareness tool, providing full graphical summaries, complete bibliographic information, and author abstracts for the papers it covers.
With Index Chemicus, a user can:
USE FILE 302to keep up on the latest chemical research activities taking place worldwide. S METH(W)OXY AND TRANSFERASEUSE DialogLinkTM5 and FILE 302to graphically search and display the chemical structures within Index Chemicus. USE CORPORATE SOURCE (CS=)to track the work of other research groups S CS=(ARIZONA(W)STATE)USE BA= and MAP BAto search for biologically active compounds and then save the biological activity terms for further searching in other files. S BA=TRYPSIN INHIBITING? MAP BA TEMP S3 |
Index Chemicus (File 302) contains the structures and critical supporting data for novel organic compounds reported in over 100 leading international journals. In addition, many full records in the database show the reaction flow from starting material to final product. Index Chemicus is a vital source of new information on biologically active compounds and natural products.
| Dates Covered: | 1993 forward |
|---|---|
| File Size: | 2.4 Million compounds from 202,000 records as of November 1, 2005 |
| Update Frequency: | Weekly 4,000 new compounds added per update from 325 articles |
| ACRONYM | CATEGORY NAME |
|---|---|
| CHEMLIT | Chemical Literature |
| CHEMSTRC | Chemical Structure Search |
| SCITECH | Science and Technology |
Index Chemicus is produced by Thomson Scientific, Inc. Questions concerning file content should be directed to:
|
Thomson Scientific, Inc. Customer Technical Support 3501 Market Street Philadelphia, PA 19104
|
Full copies of publications indexed in the Index Chemicus database may be ordered via the online "Order" function.
For Dialog's Redistribution and Archive Policy, enter HELP ERA online. The following Terms and Conditions also apply.
Buyer agrees that the material retrieved hereunder will not be used for commercial resale in any media (electronics, paper, or photographic film) and that the Buyer is licensed to use information derived from the database only for use of the Buyer, Buyer's employees, and/or Buyer's normal constituency, for one-time bibliographies in single-copy form. Except as permitted under Dialog's Redistribution and Archive policy, no part of the materials furnished or data therefrom may be copied in machine-readable form by any user for any purpose without prior agreement with Thomson Corporation.
THOMSON CORPORATION MAKES NO GUARANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INDEX CHEMICUS DATABASE. THOMSON CORPORATION SHALL IN NO EVENT BE LIABLE FOR DIRECT, INDIRECT, OR CONSEQUENTIAL DAMAGES.
| DIALOG(R)File 302:INDEX CHEMICUS | |
| (c) 2005 Thomson Corporation All rights reserved. | |
| 0000179426 | |
| /TI | Total-synthesis and in-vitro-antifungal activity of (+/-)-2- |
| methoxytetradecanoic acid | |
| AU= | Author(s): Carballeira NM; Ortiz D; Parang K; Sardari S |
| CS= | Corporate Source:Univ Puerto Rico, Dept Chem, San Juan, PR 00931 USA; |
| Univ Rhode Isl, Coll Pharm, Dept Biomed Sci, Kingston, RI 02881 USA | |
| JN=,SN= | Journal Name: ARCHIV DER PHARMAZIE 337 (3): 152-155 ISSN: 0365-6233 |
| Item Count: 0007 | |
| PD=,PY= | Publication Date: MAR, 2004 (20040300) |
| DT=,RT= | Document Type: Journal Record Type: Article |
| LA= | Language: English |
| PU= | Publisher: WILEY-V C H VERLAG GMBH, PO BOX 10 11 61, D-69451 |
| WEINHEIM, GERMANY. JOURNALS ADMINISTRATION DEPT. 1 OLDLANDS WAYS BOGNOR | |
| REGIS, W SUSSEX PO 22 9SA, ENGLAND. | |
| Structure Image or Graphical Abstract Diagram | |
 | |
| /AB | Abstract: The marine fatty acid (+/-)-2-methoxytetradecanoic acid |
| was synthesized in two steps (71% overall yield) starting from commercially | |
| available methyl-2-hydroxytetradecanoate. The title compound was antifungal | |
| against Candida albicans (ATCC 14053) in RPMI medium and Aspergillus niger | |
| (ATTCC 16404) and Cryptococcocus neoformans (ATCC 66031) in SDB medium at the | |
| minimum inhibitory concentration (MIC) of 100 mM, which compares to the | |
| fungitoxicity of a 2-iodotetradecanoic acid against the same fungi. The | |
| title compound was also five to ten times more cytotoxic than capric acid | |
| to C. albicans and A. niger in the tested medium but comparable in | |
| cytotoxicity to either capric acid and its 2-methoxylated analog to C. | |
| neoformans. The antifungal activity of () -2-methoxytetradecanoic acid is | |
| explained in terms of inhibition of N-myristoyltransferase. | |
| /DE | Descriptors: |
| KeyWords Plus: CANDIDA-ALBICANS; FATTY-ACIDS | |
| Keywords (Author): 2-METHOXYTETRADECANOIC ACID; MYRISTIC ACID; | |
| ANTIFUNGAL ACTIVITY; N-MYRISTOYLTRANSFERASE | |
| NC= | No. of Compounds: 2 |
| Compound Number: 670205001 | |
| Compound ID: 1 | |
| /DE,BA= | Bioactivity--Activity Status: |
| ANTIFUNGAL ACTIVITY--Tested | |
| ENZYME INHIBITING ACTIVITY--Tested | |
| TRANSFERASE INHIBITING ACTIVITY--Tested | |
 | |
| [Edit Molecule] | |
| ---------- | |
| Compound Number: 670205002 | |
| Compound ID: 1a | |
 | |
| [Edit Molecule] | |
| ---------- | |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields | Word | S METH(W)OXY S STRUCTUR?(W)ANALYSIS |
| /AB | AB | Abstract1 | Segment & Word |
S METH(W)OXY/AB S TUMOR(W)CELL?/AB S METHOXY/FW |
| /DE | DE | Descriptor1,2,3,4 | Segment & Word & Phrase |
S METH(W)OXY/DE S MYRISTIC(W)ACID/DE S N-MYRISTOYLTRANSFERASE/DE S CANDIDA/DF |
| /SY | SY | Trivial Chemical Name (Synonym)1,4 | Segment & Word & Phrase |
S METH(W)OXY/SY S CYCLOHEXANE/SY S PHE-GLY-ASN?/SY S ARG(S)TYR/SY |
| /TI | TI | Title1 | Segment & Word |
S TOTAL(W)SYNTHESIS/TI S AZO(W)DI/TI |
1 The chemical names (common or systematic) are indexed as chemically significant segments, individual words and complete phrases, depending on the indexing of the field the name is found in. Use /FW, Full Word, to limit to the unsegmented term.
2 Includes Bioactivity terms, KeyWords Plus and Author Keywords.
4 Searchable in the Basic Index and Additional Indexes.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| AU= | AU | Author Name | Phrase | S AU=CARBALLEIRA NM |
| None | AZ | DIALOG Accession Number | ||
| BA= | BA | Biological Activity4 | Word & Phrase |
S BA=TRANSFERASE INHIBITING ACTIVITY S BA=(TRYPSIN(W)INHIBITING) |
| CS= | CS | Corporate Source | Word & Phrase |
S CS=(ARIZONA(W)STATE) S CS=ARIZONA STATE? |
| DT= | DT | Document Type | Phrase | S DT=JOURNAL |
| None | GR | Grade | ||
| None | GS | Searchable Chemical Structure5 | ||
| None | IM | Structure Image or Graphical Abstract Diagram5 | ||
| JN= | JN | Journal Name | Phrase | S JN=ARCHIV DER PHARMAZIE |
| LA= | LA | Language | Phrase | S LA=ENGLISH |
| NA= | NA | Trivial Chemical Name (Synonym)4 | Phrase | S NA=2-DEACETYLTAXINE A S NA=ALA-LEU-ALA? S NA=CUPANIOL |
| NC= | NC | Number of Compounds7 | Phrase | S NC=02 |
| None | OT | Original Article Title | ||
| PD= | PD | Publication Date | Phrase | S PD=20040300 |
| PU= | PU | Publisher Name | Phrase | S PU=WILEY V C H? |
| PY= | PY | Publication Year | Phrase | S PY=2004 |
| RT= | RT | Record Type | Phrase | S RT=ARTICLE |
| SN= | SN | ISSN | Phrase | S SN=0365-6233 |
| None | SO | Journal Source Information6 | ||
| ST= | ST | Status of Bioactivity Testing | Phrase | ST=TESTED ST=POTENTIAL |
| SY= | SY | Trivial Chemical Name (Synonym)4 | Phrase | S SY=ALA-ASP-? S SY=CUPANIOL |
5 The graphic structure can be displayed using DialogLink 5. All other interfaces currently display the text equivalent of the .MOL file. The GS or IM display codes can be combined with any user-defined format or any pre-defined format. Structure images or graphical abstract designs are not provided after week 201226.
6 SO (journal source information) includes the journal name, volume, issue, pages, ISSN and publication date.
7 Compound Number is the sequencial number within Index Chemicus and Compound ID is the compound reference number used by the author
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| AU, JN, PD, PY, TI | SORT S6/ALL/TI |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: DE | RANK DE RANK NA S4 RANK JN S8/1-34 |
| MAP FIELDS | EXAMPLES |
|---|---|
| BA, NA, SY | MAP BA TEMP S1 |
| Display codes listed in the Search Options tables can be used to customize output. | TYPE S4/JN,SY/ALL |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Full Record, except abstract |
| 3 | Medium | Dialog Accession Number, Item Count, Number of Compounds, Title, Journal Name, Author, Corporate Source, Publisher, Language and Trivial Chemical Name |
| 4 | -- | Full Record - tagged |
| 5 | Long | Full Record |
| 6 | -- | Dialog Accession Number, Item Count, Number of Compounds and Title |
| 7 | -- | Full Record |
| 8 | Short | Dialog Accession Number, Item Count, Number of Compounds, Title, KeyWords Plus and Author Keywords |
| 9 | Full | Full Record |
| 19 | -- | Full Record |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| If the accession number of a specific record is known, it can be used to display the record directly. | TYPE 0179426/9 DISPLAY 0179426/TI,AU PRINT 0179426/3 |
||
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