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Last Loaded on Web: Wednesday, February 01, 2012
EMBASE AlertTM is a current awareness pharmacological and biomedical literature database renowned for its coverage of the drug-related literature. It is updated weekly and contains the most recent 8 weeks' worth of data, and on average contains approximately 80,000 records.
EMBASE AlertTM comprises bibliographic records that have not yet been indexed by the EMBASE editors. Most records consist of bibliographic citations containing abstracts and author-supplied keywords.
EMBASE Alert is not cumulative, but rather a "rolling" file; as a new update is added each week, the oldest week is deleted. Citations can be found with full indexing in EMBASETM (File 72) just a few weeks following their appearance in EMBASE Alert.
Citations from more than 5,000 journals from about 70 countries are included.
USE FILE 172to search for the very latest biomedical and pharmaceutical articles; use it together with EMBASE (Files 72 and 73) for both current and comprehensive information. USE FREE TEXT SEARCHINGin the Basic Index since the records include no controlled subject indexing. USE LIMITSto restrict search results to English (/ENG) or to records containing abstracts (/ABS). /p> |
| Dates Covered: | Current 8 weeks |
|---|---|
| File Size: | Approximately 170,000 records |
| Update Frequency: | Daily |
| ACRONYM | CATEGORY NAME |
|---|---|
| ALTMED | Alternative Medicine |
| BIOCHEM | Biochemistry |
| BIOSCI | Biosciences |
| BIOTECH | Biotechnology |
| HEALTH | Health |
| MEDDEV | Medical Devices |
| MEDENG | Medical Engineering |
| MEDICINE | Medicine |
| NUTRIT | Nutrition |
| PHARM | Pharmacology |
| PHARMR | Pharmacology + RINGDOC-Files |
| SAFETY | Safety |
| TOXICOL | Toxicology |
|
Elsevier B.V. P.O. Box 211 Amsterdam, 1000 AE The Netherlands
|
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| AA= | 0000153833 EMBASE No: 2008465216 |
|---|---|
| /TI | The management of exfoliative glaucoma |
| ISSUE TITLE: Glaucoma: An Open Window to Neurodegeneration and | |
| Neuroprotection | |
| AU= | Ritch R. |
| CS= | New York Eye and Ear Infirmary, New York, NY 10003, United States |
| AUTHOR EMAIL: ritchmd@earthlink.net | |
| CS= | CORRESP. AUTHOR/AFFIL: Ritch R.: New York Eye and Ear Infirmary, New |
| York, NY 10003, United States | |
| CORRESP. AUTHOR EMAIL: ritchmd@earthlink.net | |
| AU= | EDITOR(S): Osborne N.N.; Bagetta G. |
| CS= | University of Rome Tor Vergata, Dept. of Biopathol. and Diagnostic I, |
| Ophthalmological Unit, Rome, Italy; University of Oxford, Nuffield | |
| Laboratory of Ophthalmology, Oxford, United Kingdom; University of | |
| Calabria, Department of Pharmacobiology, Cosenza, Italy | |
| JN=,CP=,PD=,PY=,SO= | Progress in Brain Research ( Prog. Brain Res. ) (Netherlands) January 1, |
| 2008, 173/- (211-224) | |
| PU= | PUBLISHER: Elsevier |
| CD=,SN=,BN= | CODEN: PBRRA ISSN: 0079-6123 ISBN: 9780444532565 |
| PUBLISHER ITEM IDENTIFIER: S0079612308011151 | |
| DOI: 10.1016/S0079-6123(08)01115-1 | |
| DT=,RT= | DOCUMENT TYPE: Book Series; Review RECORD TYPE: Abstract |
| LA=,SL= | LANGUAGE: English SUMMARY LANGUAGE: English |
| NUMBER OF REFERENCES: 114 | |
| /AB | Exfoliation syndrome (XFS) is an age-related, generalized disorder of the |
| extracellular matrix characterized by the production and progressive | |
| accumulation of a fibrillar extracellular material in many ocular tissues | |
| and is the most common identifiable cause of open-angle glaucoma worldwide. | |
| XFS plays an etiologic role in open-angle glaucoma, angle-closure glaucoma, | |
| cataract, and retinal vein occlusion. It is accompanied by an increase in | |
| serious complications at the time of cataract extraction, such as zonular | |
| dialysis, capsular rupture, and vitreous loss. It is associated | |
| systemically with an increasing number of vascular disorders, hearing loss, | |
| and Alzheimer's disease. XFS appears to be a disease of elastic tissue | |
| microfibrils. The characteristic fibrils, composed of microfibrillar | |
| subunits surrounded by an amorphous matrix comprising various | |
| glycoconjugates, contain predominantly epitopes of elastic fibers, such as | |
| elastin, tropoelastin, amyloid P, vitronectin, and components of elastic | |
| microfibrils, such as fibrillin-1, fibulin-2, vitronectin, | |
| microfibril-associated glycoprotein (MAGP-1), and latent TGF-beta binding | |
| proteins (LTBP-1 and LTBP-2), the proteoglycans syndecan and versican, the | |
| extracellular chaperone clusterin, the cross-linking enzyme lysyl oxidase, | |
| and other proteins. A recent milestone study showed that two common single | |
| nucleotide polymorphisms in the coding region of the lysyl oxidase-like 1 | |
| (LOXL1) gene located on chromosome 15 were specifically associated with XFS | |
| and XFG. LOXL1 is a member of the lysyl oxidase family of enzymes, which | |
| are essential for the formation, stabilization, maintenance, and remodeling | |
| of elastic fibers and prevent age-related loss of elasticity of tissues. | |
| LOXL1 protein is a major component of exfoliation deposits and appears to | |
| play a role in its accumulation and in concomitant elastotic processes in | |
| intra- and extraocular tissues of XFS patients. This discovery should open | |
| the way to new approaches and directions of therapy for this protein | |
| disorder. (c) 2008 Elsevier B.V. All rights reserved. | |
| /ID | AUTHOR KEYWORDS: conformational disorder; exfoliation syndrome; exfoliative |
| glaucoma; extracellular matrix; fibrillin; glaucoma; LOXL1 |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields | Word | S PROTEIN(W)DISORDER |
| /AB | AB | Abstract1 | Word | S OCCULAR(W)TISSUES/AB |
| /ID | ID | Author-Supplied Keywords1,2,3 | Word & Phrase |
S FIBRILLIN/ID S EXTRACELLULAR MATRIX/ID |
| /TI | TI | English Title, Original Non-English Title, or Issue Title | Word | S EXFOLIATIVE(W)GLAUCOMA/TI |
1 Not present in every record.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| AA= | AA | EMBASE ID Number | Phrase | S AA=2008465216 |
| AU= | AU | Author | Phrase | S AU=RITCH R. |
| None | AZ | DIALOG Accession Number | ||
| BN= | BN | International Standard Book Number | Phrase | S BN=9780444532565 |
| CD= | CD | CODEN | Phrase | S CD=PBRRA |
| CP= | CP | Country of Publication | Word & Phrase |
S CP=NETHERLANDS S CP=HONG KONG |
| CS= | CS | Corporate Source | Word & Phrase |
S CS=(NEW(W)YORK(W)EYE) S CS=NEW YORK EYE 'AND' EAR? |
| DT= | DT | Document Type | Phrase | S DT=BOOK SERIES |
| None | II | Publisher Item Identifier (PII) or Digital Object Identifier | ||
| JN= | JN | Journal Name | Phrase | S JN=PROGRESS IN BRAIN RESEARCH |
| LA= | LA | Language | Phrase | S LA=ENGLISH |
| NO= | NO | Article Number | Phrase | S NO=C02108SS |
| PD= | PD | Publication Date | Phrase | S PD=20080101 |
| PU= | PU | Publisher | Word | S PU=ELSEVIER |
| PY= | PY | Publication Year | Phrase | S PY=2008 |
| None | RF | Number of References | ||
| RT= | RT | Record Type | Phrase | S RT=ABSTRACT |
| SL= | SL | Summary Language | Phrase | S SL=ENGLISH |
| SN= | SN | International Standard Serial Number (ISSN) | Phrase | S SN=0079-6123 S SN=00796123 |
| SO= | SO | Source Information | Word | S SO=(PROG(W)BRAIN(W)RES? AND 173) |
| UD= | None | Update | Phrase | S UD=9999 |
| SUFFIX | FIELD NAME | EXAMPLES |
|---|---|---|
| /ABS | Abstract Present | S PHYSICAL ACTIVITY/ID,ABS |
| /ENG | English Language | S ALZHEIMER(W)S/TI,ENG |
| /NOABS | No Abstract Present | S S1/NOABS |
| /NOENG | Non-English Language | S S2/NONENG |
| /YYYY | Publication Year | S NUTRITION(F)CHILD?/2008 |
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| AU, CS, JN, PY, TI | SORT S1/ALL/AU |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: BN | RANK ID RANK AU S4 |
| Display codes listed in the Search Options tables can be used to customize output. | TYPE S3/TI,ID/1-5 |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Full Record except Abstract |
| 3 | Medium | Bibliographic Citation |
| 4 | -- | Full Record with Tagged Fields1 |
| 5 | -- | Full Record1 |
| 6 | Free | Title |
| 7 | Long | Bibliographic Citation and Abstract1 |
| 8 | Short | Title |
| 9 | Full | Full Record1 |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| If the accession number of a specific record is known, it can be used to display the record directly. | TYPE 169293/9 DISPLAY 168850/TI,AU PRINT 171941/7 |
||
Rates For File: EMBASE® Alert[172]
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Cost per minute: $3.56
Rank Elements $0.00
ALERT (default) $9.81
ALERT (Monthly) * $64.64
ALERT (Biweekly/twice a month) * $54.82
ALERT (Weekly) $44.70
ALERT (Daily) $9.81
ALERT (Calendar weekly) * $44.70
ALERT (Intraday) * $9.81
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ALERT Number of included prints 20
Format Types Prints
1 $0.00 $0.00
2 $5.65 $5.65
3 $5.65 $5.65
4 $5.65 $5.65
5 $5.65 $5.65
6 $0.00 $0.00
7 $5.65 $5.65
8 $0.00 $0.00
9 $5.65 $5.65
KWIC95 $0.57 NA
KWIC96 $0.57 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
