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159
CANCERLIT®

Last Loaded on Web: Monday, April 01, 2013

Last Update To Bluesheet: October 27, 2008

Bluesheet Contents     PDF version

File Description Print Counterparts Geographic Coverage Terms and Conditions Limit Predefined Format Options
Subject Coverage Dialog File Data Special Features Sample Record Sort Rates
Sources Database Content DIALINDEX/OneSearch Categories Basic Index Rank
Tips Document Types Indexed Contact Additional Indexes Map


File Description [top]

CANCERLIT® is produced by the International Cancer Research DataBank Branch (ICRDB) of the U.S. National Cancer Institute. The database consists of bibliographic records referencing cancer research publications dating from 1963 to 2002. Most records contain abstracts, and all records contain citation information and additional descriptive fields such as document type and language. Beginning with the June 1983 CANCERLIT update, records from the MEDLINE® database dealing with cancer topics have been added to CANCERLIT.

Records added to CANCERLIT since January 1980 are indexed using the U.S. National Library of Medicine (NLM) Medical Subject Heading (MeSH®). The CANCERLIT records with MeSH descriptors are updated annually with the current version of MeSH headings. An online thesaurus is available to aid in locating MeSH descriptors. All records added before June 1983 have abstracts; approximately 75% of the records added since June 1983 have abstracts.



Tips [top]

USE THE (L) OPERATOR

to link descriptors and subheadings:

     S PROTEIN KINASES(L)ME
      S CELL DIVISION(L)DRUG EFFECTS

USE EXPLODE (!)

to search narrower descriptors in the MeSH vocabulary:

     S TUMOR CELLS, CULTURED!

USE THE ONLINE THESAURUS

to check and select MeSH thesaurus terms:

     E (DNA DAMAGE)

USE MAP

to take CAS® Registry Numbers to another file:

     MAP RN TEMP S1

USE LIMITS

     /HUMAN for human subjects      /ENG for English-language articles



Subject Coverage [top]

  • All aspects of experimental and clinical cancer therapy
  • Biochemistry, immunology, physiology, and other biology of cancer, both in vivo and in vitro
  • Chemical, viral, and other agents that cause cancer
  • Mechanisms of carcinogenesis
  • Studies of mutagens, mutagen testing, and growth factors or other agents that stimulate cell division


Sources [top]

CANCERLIT includes indexing for articles from more than 3,500 journals; approximately 200 core journals contribute a large percentage of the citations. Selected records are taken from the MEDLINE database beginning in June 1983. In addition, proceedings of meetings, government reports, symposia reports, selected monographs, and theses are also abstracted for inclusion in the database.



Print Counterparts [top]

  • None


Dialog File Data [top]

Dates Covered: 1975 to 2002
File Size: 1,862,685 records
Update Frequency: Closed


Database Content [top]

  • Bibliographic Records


Document Types Indexed [top]

  • Reports
  • Books and Monographs
  • Conferences, Symposia, Meetings
  • Government Documents
  • Journal Articles
  • Theses


Geographic Coverage [top]

  • International


Geographic Restrictions [top]

  • None


Special Features [top]

  • ERA Available
  • Graduate Education Program
  • KWIC and HILIGHT Available
  • DIALOG Alert Available
  • Remove Duplicates (RD, ID) Available
  • CURRENT Feature Available
  • Abstracts Available for 75% of the records


DialIndex/OneSearch Categories [top]

ACRONYM CATEGORY NAME
CASREGNO CAS(R) Registry Numbers-Chemical and Medical Files
MEDICINE Medicine
NURSING Nursing and Health Administration
RNMED CAS(R) Registry Numbers - Medical Files


Contact [top]

CANCERLIT is produced by the U.S. National Cancer Institute (NCI). Questions concerning file content should be directed to:

National Cancer Institute
Licensing and Distribution Program
6116 Executive Blvd, Suite 300A
Rockville, MD 20852-4920

Telephone: 1-301-496-1277
800 Line: 800-4-CANCER
Fax: 1-301-480-8105


Terms and Conditions [top]

CANCERLIT is a registered trademark of the National Library of Medicine

Some material in this Database is from copyrighted publications of the respective copyright claimants. Users of the Database are referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publication, all of which are hereby incorporated by reference. NCI represents that the Database is formulated with a reasonable standard of care. Except for this representation, and as otherwise specifically provided, NCI makes no representations or warranties, express or implied, including any implied warranty of merchantability or fitness for a particular purpose, with respect to the Database. Licensee shall inform all users of this limitation in writing.

A user may electronically archive information in machine-readable form for no more than twelve (12) months. Retention of the input date field is recommended to ensure accurate and timely purging of archived information. User shall be responsible for incorporating current updates into such archived information. Further, redistribution and/or archiving requires the intent not to create a derivative work. Specifically, derivative works which facilitate insurance reimbursement or financially based patient care decisions are expressly not permitted.


Dialog Standard Terms & Conditions apply.


SAMPLE RECORD [top]

    DIALOG(R)File 159:Cancerlit 
    (c) format only 2001 Dialog Corporation. All rts. reserv. 
     
  AN=,AA=  10724612   20270250   PMID: 10809772 
  /TI   Distinct   Chk2  activation  pathways  are  triggered  by  genistein  and 
    DNA-damaging agents in human melanoma cells. 
  AU=    Darbon  JM;  Penary  M;  Escalas  N;  Casagrande  F;  Goubin-Gramatica F; 
    Baudouin C; Ducommun B 
  CS=    Laboratoire  de  Biologie  Cellulaire  et  Moleculaire  du Controle de la 
    Proliferation  Cellulaire,  UMR  5088  CNRS,  Universite Paul Sabatier, 118 
    Route de Narbonne, 31062 Toulouse Cedex, France. darbon@cict.fr 
  JN=,SO=,CP=,PY=    Journal of biological chemistry (UNITED STATES)   May 19 2000,  275  (20) 
  SN=,JC=  p15363-9,  ISSN 0021-9258   Journal Code: 2985121R 
  DT=    Document type: Journal Article 
  LA=    Languages: ENGLISH 
  OA=    Main Citation Owner: NLM 
  SF=    Subfile: INDEX MEDICUS 
  /AB    Genistein,  a  natural  isoflavone  found in soybeans, exerts a number of 
    biological actions suggesting that it may have a role in cancer prevention. 
    We  have  previously  shown  that  it potently inhibits OCM-1 melanoma cell 
    proliferation  by  inducing  a  G(2)  cell  cycle arrest. Here we show that 
    genistein  exerts  this  effect  by  impairing  the Cdc25C-dependent Tyr-15 
    dephosphorylation of Cdk1, as the overexpression of this phosphatase allows 
    the   cells   to  escape  G(2)  arrest  and  enter  an  abnormal  chromatin 
    condensation  stage.  Caffeine totally overrides the genistein-induced G(2) 
    arrest,  whereas  the  block  caused  by etoposide is not bypassed and that 
    caused  by  adriamycin  is  only  partially  abolished. We also report that 
    genistein  activates  the  checkpoint kinase Chk2 as efficiently as the two 
    genotoxic agents and that caffeine may counteract the activation of Chk2 by 
    genistein  but  not  by  etoposide.  In  contrast,  caffeine  abolishes the 
    accumulation  of  p53  caused  by  all  the  compounds. Wortmannin does not 
    suppress  the  Chk2 activation in any situation, suggesting that the ataxia 
    telangiectasia-mutated  kinase is not involved in this regulation. Finally, 
    unlike  etoposide and adriamycin, genistein induces only a weak response in 
    terms  of  DNA damage in OCM-1 cells. Taken together, these results suggest 
    that  the  G(2)  checkpoints  activated  by genistein and the two genotoxic 
    agents involve different pathways. 
  /GS    Tags: Human; Support, Non-U.S. Gov't 
  /DE    Major Descriptors: *Caffeine--pharmacology--PD; *Cell Cycle--drug effects 
    --DE;   *Cell   Division--drug   effects--DE;   *DNA  Damage;  *Doxorubicin 
    --pharmacology--PD;  *Etoposide--pharmacology--PD; *Genistein--pharmacology 
    --PD; *Protein Kinases--metabolism--ME 
      Minor Descriptors: Cell Cycle Proteins--metabolism--ME; Choroid Neoplasms 
    ;  Enzyme  Activation;  G2  Phase;  Melanoma;  Tumor Cells, Cultured; cdc25 
    Phosphatase--metabolism--ME 
  /ID,RN=    CAS  Registry  No.:  0    (Cdc25C  protein);  0    (Cell Cycle Proteins); 
    23214-92-8   (Doxorubicin); 33419-42-0   (Etoposide); 446-72-0  (Genistein) 
    ; 58-08-2   (Caffeine) 
  /ID,EC=    Enzyme  No.: EC 2.7.1.-   (Cds1 kinase); EC 2.7.1.37   (Protein Kinases); 
    EC 3.1.3.-   (cdc25 Phosphatase) 
  UP=    Record Date Created: 20000621 


BASIC INDEX [top]

SEARCH
SUFFIX		 DISPLAY
CODE		 FIELD NAME
 INDEXING
 SELECT EXAMPLES
None None All Basic Index Fields Word S GENOTOXIC(W)AGENT?
/AB AB Abstract1 Word S MELANOMA(W)CELL?/AB
/DE DE Descriptor2,3 Word
& Phrase		 S PROTEIN(W)KINASES/DE
S CHOROID NEOPLASMS/DE
/GS GS Check Tags3 Word
& Phrase		 S SUPPORT(3W)GOV?/GS
S SUPPORT, NON-U.S. GOV'T/GS
/ID ID Identifier 4,5,6 Word
& Phrase		 S CELL(W)CYCLE(W)PROTEIN?/ID
S CDS25C PROTEIN/ID
/NM NM Named Person Word
& Phrase		 S DIXON(1W)J/NM
S MURPHY G P/NM
/TI TI Title Word S HUMAN(W)MELANOMA(W)CELL?/TI

1 Abstracts present for all records added before June 1983 and for 75% of records added after June 1983.

2 Also /DE*, /DF, /DF*.

3 Records added prior to January 1980 do not have MeSH descriptors or check tags.

4 Also /IF. Includes CAS Registry Number, Enzyme Commission Number, Gene Symbol, Enzyme Name, Chemical Name.

5 Beginning in June 1983 for MEDLINE-derived records, and beginning in June 1985 for all other records. Includes gene symbol in 1991-1995 searchable using /DE or /ID and displayable either in the DE or the ID field.

6 Chemical Names and Enzyme Names are searchable in the Basic Index as /ID; CAS Registry Number and Enzyme Commission Number are searchable in the Additional Indexes as EC= and RN=, displayable in the RN or the EC field.


ADDITIONAL INDEXES [top]

SEARCH
PREFIX		 DISPLAY
CODE		 FIELD NAME
 INDEXING
 SELECT EXAMPLES
AA= AA PubMed Unic Identifier (PMID) Phrase S AA=10809772
None AN DIALOG Accession Number
AN= AN NLM Accession Number Phrase S AN=20270250
AU= AU Author Phrase S AU=DARBON JM
CN= CN Contract/Grant Number7 Phrase S CN=CA44579
CP= CP Country of Publication Phrase S CP=UNITED STATES
CS= CS Corporate Source Word
& Phrase		 S CS=(UNIVERSITE(W)PAUL(W)SABATIER)
S CS=LABORATOIRE DE BIOLOGIE?
DC= None Descriptor Code8 Phrase S DC=G4.335.135.
DT= DT Document Type Phrase S DT=JOURNAL ARTICLE
EC= EC Enzyme Commission Number Phrase S EC=2.7.1.37
JC= JC Journal Code9 Phrase S JC=2985121R
JN= JN Journal Name10 Phrase S JN=JOURNAL OF BIOLOGICAL CHEMISTRY
LA= LA Language Phrase S LA=ENGLISH
MI= MI Mission Name Phrase S MI=SHORT DURATION
NT= NT Note/Comment11 Word S NT=(CANCER(W)INVEST?)
OA= OA Main Citation Owner Phrase S OA=NLM
OB= OB Other Citation Owner Phrase S OB=KIE
OC= OC Abstract Source Phrase S OC=NASA
PY= PY Publication Year Phrase S PY=2000
None RF Number of References
RI= RI Record Identifier13 Phrase S RI=00016051
RN= RN CAS(R) Registry Number12 Phrase S RN=23214-92-8
RT= RT Record Type Phrase S RT=COMPLETED
SF= SF Subfile Phrase S SF=INDEX MEDICUS
SN= SN International Standard Serial Number (ISSN)13 Phrase S SN=0021-9258
SO= SO Source Information14 Word S SO=(JOURNAL(2W)CHEMISTRY AND 275)
SQ= SQ Molecular Sequence Databank Number15 Word
& Phrase		 S SQ=(GENBANK(W)AA129848)
S SQ="GENBANK/H25417"
UD= None Update Phrase S UD=9999
UP= UP Record Date Created16 Phrase S UP=20000621

7 For MEDLINE-derived records beginning in June 1980.

8 Descriptor Code Explodes can also be searched using the descriptor name followed by an exclamation mark (i.e., SELECT CELLS, CULTURED!). Descriptor codes do not display in records.

9 Beginning in June 1980 for journals indexed by NLM.

10 Journal Names are searchable as either the full name or the abbreviated name depending on a record; displayable as the abbreviated name.

11 Beginning in 1989 for MEDLINE-derived records only.

12 Beginning in June 1980 for MEDLINE records and in June 1985 for all other records.

13 Not present in all records.

14 Search and Display include Journal Name, Volume, Issue, Pagination, and Publication Year.

15 For records from 1996 forward.

16 The date NLM originally put the record into the database.


LIMIT [top]

SUFFIX FIELD NAME EXAMPLES
/ABS Abstract Present S S3/ABS
/ENG English-Language Documents S S2/ENG
/HUMAN Human Subject S S1/HUMAN
/MAJ Major Descriptor S S5/MAJ
/NOABS No Abstract Present S S4/NOABS
/NONENG Non-English Language Documents S S6/NONENG
/YYYY Publication Year S S7/2000


SORT [top]

SORTABLE FIELDS EXAMPLES
AU, CS, JN, PY, TI SORT S3/ALL/AU
SORT S1/ALL/PY/D


RANK [top]

RANK FIELDS EXAMPLES
All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: DE, ID RANK AU S3
RANK DE S1


MAP [top]

MAP FIELDS EXAMPLES
RN MAP CS TEMP S1
MAP RN TEMP S2


USER-DEFINED FORMAT OPTIONS [top]

User-defined formats may be specified using the display codes indicated in the Search Options tables. TYPE S2/AU,TI/1-5
PRINT S1/TI,AB/ALL


PREDEFINED FORMAT OPTIONS [top]

NO.
 DIALOGWEB
FORMAT		 RECORD CONTENT
1 -- DIALOG Accession Number
2 -- Full Record except Abstract
3 Medium Bibliographic Citation
4 -- Full Record with Tagged Fields1
5 -- Full Record1
6 Short Title and Publication Year
7 Long Bibliographic Citation and Abstract1
8 Free Title, Indexing and Publication Year
9 Full Full Record1
K -- KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats


DIRECT RECORD ACCESS [top]

FIELD NAME EXAMPLES
DIALOG Accession Number TYPE 03869010/5
DISPLAY 03870556/AU,TI
PRINT 03825646/9


Rates [top]

Rates For File: CANCERLIT®[159]
Cost per DialUnit:                 $4.50
Cost per minute:                   $0.88
Rank Elements                      $0.00

Format    Types   Prints
     1    $0.00    $0.00
     2    $0.60    $0.60
     3    $0.60    $0.60
     4    $0.60    $0.60
     5    $0.60    $0.60
     6    $0.00    $0.00
     7    $0.60    $0.60
     8    $0.00    $0.00
     9    $0.75    $0.75
KWIC95    $0.08       NA
KWIC96    $0.08       NA

REDIST/COPY Multiplier Table:

      Range      Multiplier
        1-2       1.00
       3-25       1.50
     26-100       3.00
    101-200       4.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

ARCHIVE Multiplier Table:

      Range      Multiplier
       1-25       1.50
     26-200       3.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00
[top]


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