CANCERLIT [159]

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	159
CANCERLIT®

Last Loaded on Web: Wednesday, May 01, 2013

Last Update To Bluesheet: October 27, 2008

Bluesheet Contents PDF version

File Description	Print Counterparts	Geographic Coverage	Terms and Conditions	Limit	Predefined Format Options
Subject Coverage	Dialog File Data	Special Features	Sample Record	Sort	Rates
Sources	Database Content	DIALINDEX/OneSearch Categories	Basic Index	Rank
Tips	Document Types Indexed	Contact	Additional Indexes	Map

File Description [top]

CANCERLIT^® is produced by the International Cancer Research DataBank Branch (ICRDB) of the U.S. National Cancer Institute. The database consists of bibliographic records referencing cancer research publications dating from 1963 to 2002. Most records contain abstracts, and all records contain citation information and additional descriptive fields such as document type and language. Beginning with the June 1983 CANCERLIT update, records from the MEDLINE^® database dealing with cancer topics have been added to CANCERLIT.

Records added to CANCERLIT since January 1980 are indexed using the U.S. National Library of Medicine (NLM) Medical Subject Heading (MeSH^®). The CANCERLIT records with MeSH descriptors are updated annually with the current version of MeSH headings. An online thesaurus is available to aid in locating MeSH descriptors. All records added before June 1983 have abstracts; approximately 75% of the records added since June 1983 have abstracts.

Tips [top]

USE THE (L) OPERATOR

to link descriptors and subheadings:

S PROTEIN KINASES(L)ME S CELL DIVISION(L)DRUG EFFECTS

USE EXPLODE (!)

to search narrower descriptors in the MeSH vocabulary:

S TUMOR CELLS, CULTURED!

USE THE ONLINE THESAURUS

to check and select MeSH thesaurus terms:

E (DNA DAMAGE)

USE MAP

to take CAS® Registry Numbers to another file:

MAP RN TEMP S1

USE LIMITS

/HUMAN for human subjects /ENG for English-language articles

Subject Coverage [top]

All aspects of experimental and clinical cancer therapy
Biochemistry, immunology, physiology, and other biology of cancer, both in vivo and in vitro
Chemical, viral, and other agents that cause cancer
Mechanisms of carcinogenesis
Studies of mutagens, mutagen testing, and growth factors or other agents that stimulate cell division

Sources [top]

CANCERLIT includes indexing for articles from more than 3,500 journals; approximately 200 core journals contribute a large percentage of the citations. Selected records are taken from the MEDLINE database beginning in June 1983. In addition, proceedings of meetings, government reports, symposia reports, selected monographs, and theses are also abstracted for inclusion in the database.

Print Counterparts [top]

None

Dialog File Data [top]

Dates Covered:	1975 to 2002
File Size:	1,862,685 records
Update Frequency:	Closed

Database Content [top]

Bibliographic Records

Document Types Indexed [top]

Reports
Books and Monographs
Conferences, Symposia, Meetings
Government Documents
Journal Articles
Theses

Geographic Coverage [top]

International

Geographic Restrictions [top]

None

Special Features [top]

ERA Available
Graduate Education Program
KWIC and HILIGHT Available
DIALOG Alert Available
Remove Duplicates (RD, ID) Available
CURRENT Feature Available
Abstracts Available for 75% of the records

DialIndex/OneSearch Categories [top]

ACRONYM	CATEGORY NAME
CASREGNO	CAS(R) Registry Numbers-Chemical and Medical Files
MEDICINE	Medicine
NURSING	Nursing and Health Administration
RNMED	CAS(R) Registry Numbers - Medical Files

Contact [top]

CANCERLIT is produced by the U.S. National Cancer Institute (NCI). Questions concerning file content should be directed to:

National Cancer Institute
Licensing and Distribution Program
6116 Executive Blvd, Suite 300A
Rockville, MD 20852-4920

Telephone:	1-301-496-1277
800 Line:	800-4-CANCER
Fax:	1-301-480-8105

Terms and Conditions [top]

CANCERLIT is a registered trademark of the National Library of Medicine

Some material in this Database is from copyrighted publications of the respective copyright claimants. Users of the Database are referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publication, all of which are hereby incorporated by reference. NCI represents that the Database is formulated with a reasonable standard of care. Except for this representation, and as otherwise specifically provided, NCI makes no representations or warranties, express or implied, including any implied warranty of merchantability or fitness for a particular purpose, with respect to the Database. Licensee shall inform all users of this limitation in writing.

A user may electronically archive information in machine-readable form for no more than twelve (12) months. Retention of the input date field is recommended to ensure accurate and timely purging of archived information. User shall be responsible for incorporating current updates into such archived information. Further, redistribution and/or archiving requires the intent not to create a derivative work. Specifically, derivative works which facilitate insurance reimbursement or financially based patient care decisions are expressly not permitted.

Dialog Standard Terms & Conditions apply.

SAMPLE RECORD [top]

	`DIALOG(R)File 159:Cancerlit`
	`(c) format only 2001 Dialog Corporation. All rts. reserv.`

AN=,AA=	`10724612 20270250 PMID: 10809772`
/TI	`Distinct Chk2 activation pathways are triggered by genistein and`
	`DNA-damaging agents in human melanoma cells.`
AU=	`Darbon JM; Penary M; Escalas N; Casagrande F; Goubin-Gramatica F;`
	`Baudouin C; Ducommun B`
CS=	`Laboratoire de Biologie Cellulaire et Moleculaire du Controle de la`
	`Proliferation Cellulaire, UMR 5088 CNRS, Universite Paul Sabatier, 118`
	`Route de Narbonne, 31062 Toulouse Cedex, France. darbon@cict.fr`
JN=,SO=,CP=,PY=	`Journal of biological chemistry (UNITED STATES) May 19 2000, 275 (20)`
SN=,JC=	`p15363-9, ISSN 0021-9258 Journal Code: 2985121R`
DT=	`Document type: Journal Article`
LA=	`Languages: ENGLISH`
OA=	`Main Citation Owner: NLM`
SF=	`Subfile: INDEX MEDICUS`
/AB	`Genistein, a natural isoflavone found in soybeans, exerts a number of`
	`biological actions suggesting that it may have a role in cancer prevention.`
	`We have previously shown that it potently inhibits OCM-1 melanoma cell`
	`proliferation by inducing a G(2) cell cycle arrest. Here we show that`
	`genistein exerts this effect by impairing the Cdc25C-dependent Tyr-15`
	`dephosphorylation of Cdk1, as the overexpression of this phosphatase allows`
	`the cells to escape G(2) arrest and enter an abnormal chromatin`
	`condensation stage. Caffeine totally overrides the genistein-induced G(2)`
	`arrest, whereas the block caused by etoposide is not bypassed and that`
	`caused by adriamycin is only partially abolished. We also report that`
	`genistein activates the checkpoint kinase Chk2 as efficiently as the two`
	`genotoxic agents and that caffeine may counteract the activation of Chk2 by`
	`genistein but not by etoposide. In contrast, caffeine abolishes the`
	`accumulation of p53 caused by all the compounds. Wortmannin does not`
	`suppress the Chk2 activation in any situation, suggesting that the ataxia`
	`telangiectasia-mutated kinase is not involved in this regulation. Finally,`
	`unlike etoposide and adriamycin, genistein induces only a weak response in`
	`terms of DNA damage in OCM-1 cells. Taken together, these results suggest`
	`that the G(2) checkpoints activated by genistein and the two genotoxic`
	`agents involve different pathways.`
/GS	`Tags: Human; Support, Non-U.S. Gov't`
/DE	`Major Descriptors: Caffeine--pharmacology--PD; Cell Cycle--drug effects`
	`--DE; Cell Division--drug effects--DE; DNA Damage; *Doxorubicin`
	`--pharmacology--PD; Etoposide--pharmacology--PD; Genistein--pharmacology`
	`--PD; *Protein Kinases--metabolism--ME`
	`Minor Descriptors: Cell Cycle Proteins--metabolism--ME; Choroid Neoplasms`
	`; Enzyme Activation; G2 Phase; Melanoma; Tumor Cells, Cultured; cdc25`
	`Phosphatase--metabolism--ME`
/ID,RN=	`CAS Registry No.: 0 (Cdc25C protein); 0 (Cell Cycle Proteins);`
	`23214-92-8 (Doxorubicin); 33419-42-0 (Etoposide); 446-72-0 (Genistein)`
	`; 58-08-2 (Caffeine)`
/ID,EC=	`Enzyme No.: EC 2.7.1.- (Cds1 kinase); EC 2.7.1.37 (Protein Kinases);`
	`EC 3.1.3.- (cdc25 Phosphatase)`
UP=	`Record Date Created: 20000621`

BASIC INDEX [top]

SEARCH SUFFIX	DISPLAY CODE	FIELD NAME	INDEXING	SELECT EXAMPLES
None	None	All Basic Index Fields	Word	S GENOTOXIC(W)AGENT?
/AB	AB	Abstract¹	Word	S MELANOMA(W)CELL?/AB
/DE	DE	Descriptor^2,3	Word & Phrase	S PROTEIN(W)KINASES/DE S CHOROID NEOPLASMS/DE
/GS	GS	Check Tags³	Word & Phrase	S SUPPORT(3W)GOV?/GS S SUPPORT, NON-U.S. GOV'T/GS
/ID	ID	Identifier ^4,5,6	Word & Phrase	S CELL(W)CYCLE(W)PROTEIN?/ID S CDS25C PROTEIN/ID
/NM	NM	Named Person	Word & Phrase	S DIXON(1W)J/NM S MURPHY G P/NM
/TI	TI	Title	Word	S HUMAN(W)MELANOMA(W)CELL?/TI

¹Abstracts present for all records added before June 1983 and for 75% of records added after June 1983.

²Also /DE*, /DF, /DF*.

³Records added prior to January 1980 do not have MeSH descriptors or check tags.

⁴Also /IF. Includes CAS Registry Number, Enzyme Commission Number, Gene Symbol, Enzyme Name, Chemical Name.

⁵Beginning in June 1983 for MEDLINE-derived records, and beginning in June 1985 for all other records. Includes gene symbol in 1991-1995 searchable using /DE or /ID and displayable either in the DE or the ID field.

⁶Chemical Names and Enzyme Names are searchable in the Basic Index as /ID; CAS Registry Number and Enzyme Commission Number are searchable in the Additional Indexes as EC= and RN=, displayable in the RN or the EC field.

ADDITIONAL INDEXES [top]

SEARCH PREFIX	DISPLAY CODE	FIELD NAME	INDEXING	SELECT EXAMPLES
AA=	AA	PubMed Unic Identifier (PMID)	Phrase	S AA=10809772
None	AN	DIALOG Accession Number
AN=	AN	NLM Accession Number	Phrase	S AN=20270250
AU=	AU	Author	Phrase	S AU=DARBON JM
CN=	CN	Contract/Grant Number⁷	Phrase	S CN=CA44579
CP=	CP	Country of Publication	Phrase	S CP=UNITED STATES
CS=	CS	Corporate Source	Word & Phrase	S CS=(UNIVERSITE(W)PAUL(W)SABATIER) S CS=LABORATOIRE DE BIOLOGIE?
DC=	None	Descriptor Code⁸	Phrase	S DC=G4.335.135.
DT=	DT	Document Type	Phrase	S DT=JOURNAL ARTICLE
EC=	EC	Enzyme Commission Number	Phrase	S EC=2.7.1.37
JC=	JC	Journal Code⁹	Phrase	S JC=2985121R
JN=	JN	Journal Name¹⁰	Phrase	S JN=JOURNAL OF BIOLOGICAL CHEMISTRY
LA=	LA	Language	Phrase	S LA=ENGLISH
MI=	MI	Mission Name	Phrase	S MI=SHORT DURATION
NT=	NT	Note/Comment¹¹	Word	S NT=(CANCER(W)INVEST?)
OA=	OA	Main Citation Owner	Phrase	S OA=NLM
OB=	OB	Other Citation Owner	Phrase	S OB=KIE
OC=	OC	Abstract Source	Phrase	S OC=NASA
PY=	PY	Publication Year	Phrase	S PY=2000
None	RF	Number of References
RI=	RI	Record Identifier¹³	Phrase	S RI=00016051
RN=	RN	CAS(R) Registry Number¹²	Phrase	S RN=23214-92-8
RT=	RT	Record Type	Phrase	S RT=COMPLETED
SF=	SF	Subfile	Phrase	S SF=INDEX MEDICUS
SN=	SN	International Standard Serial Number (ISSN)¹³	Phrase	S SN=0021-9258
SO=	SO	Source Information¹⁴	Word	S SO=(JOURNAL(2W)CHEMISTRY AND 275)
SQ=	SQ	Molecular Sequence Databank Number¹⁵	Word & Phrase	S SQ=(GENBANK(W)AA129848) S SQ="GENBANK/H25417"
UD=	None	Update	Phrase	S UD=9999
UP=	UP	Record Date Created¹⁶	Phrase	S UP=20000621

⁷For MEDLINE-derived records beginning in June 1980.

⁸Descriptor Code Explodes can also be searched using the descriptor name followed by an exclamation mark (i.e., SELECT CELLS, CULTURED!). Descriptor codes do not display in records.

⁹Beginning in June 1980 for journals indexed by NLM.

¹⁰Journal Names are searchable as either the full name or the abbreviated name depending on a record; displayable as the abbreviated name.

¹¹Beginning in 1989 for MEDLINE-derived records only.

¹²Beginning in June 1980 for MEDLINE records and in June 1985 for all other records.

¹³Not present in all records.

¹⁴Search and Display include Journal Name, Volume, Issue, Pagination, and Publication Year.

¹⁵For records from 1996 forward.

¹⁶The date NLM originally put the record into the database.

LIMIT [top]

SUFFIX	FIELD NAME	EXAMPLES
/ABS	Abstract Present	S S3/ABS
/ENG	English-Language Documents	S S2/ENG
/HUMAN	Human Subject	S S1/HUMAN
/MAJ	Major Descriptor	S S5/MAJ
/NOABS	No Abstract Present	S S4/NOABS
/NONENG	Non-English Language Documents	S S6/NONENG
/YYYY	Publication Year	S S7/2000

SORT [top]

SORTABLE FIELDS	EXAMPLES
AU, CS, JN, PY, TI	SORT S3/ALL/AU SORT S1/ALL/PY/D

RANK [top]

RANK FIELDS	EXAMPLES
All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: DE, ID	RANK AU S3 RANK DE S1

MAP [top]

MAP FIELDS	EXAMPLES
RN	MAP CS TEMP S1 MAP RN TEMP S2

USER-DEFINED FORMAT OPTIONS [top]


User-defined formats may be specified using the display codes indicated in the Search Options tables.	TYPE S2/AU,TI/1-5 PRINT S1/TI,AB/ALL

PREDEFINED FORMAT OPTIONS [top]

NO.	DIALOGWEB FORMAT	RECORD CONTENT
1	--	DIALOG Accession Number
2	--	Full Record except Abstract
3	Medium	Bibliographic Citation
4	--	Full Record with Tagged Fields¹
5	--	Full Record¹
6	Short	Title and Publication Year
7	Long	Bibliographic Citation and Abstract¹
8	Free	Title, Indexing and Publication Year
9	Full	Full Record¹
K	--	KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats

DIRECT RECORD ACCESS [top]

FIELD NAME	EXAMPLES
DIALOG Accession Number	TYPE 03869010/5 DISPLAY 03870556/AU,TI PRINT 03825646/9

Rates [top]

Rates For File: CANCERLIT^®[159]
Cost per DialUnit:                 $4.50
Cost per minute:                   $0.88
Rank Elements                      $0.00

Format    Types   Prints
     1    $0.00    $0.00
     2    $0.60    $0.60
     3    $0.60    $0.60
     4    $0.60    $0.60
     5    $0.60    $0.60
     6    $0.00    $0.00
     7    $0.60    $0.60
     8    $0.00    $0.00
     9    $0.75    $0.75
KWIC95    $0.08       NA
KWIC96    $0.08       NA

REDIST/COPY Multiplier Table:

      Range      Multiplier
        1-2       1.00
       3-25       1.50
     26-100       3.00
    101-200       4.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

ARCHIVE Multiplier Table:

      Range      Multiplier
       1-25       1.50
     26-200       3.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

[top]