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153
IPA Toxicology

Last Loaded on Web: Wednesday, May 01, 2013

Last Update To Bluesheet: January 15, 2006

Bluesheet Contents     PDF version

File Description Print Counterparts Special Features Sample Record Sort Rates
Subject Coverage Dialog File Data DIALINDEX/OneSearch Categories Basic Index Rank
Sources Document Types Indexed Contact Additional Indexes Map
Tips Geographic Coverage Terms and Conditions Limit Predefined Format Options


File Description [top]

IPA Toxicology is a subset of the International Pharmaceutical Abstracts database (File 74) providing focused toxicology information on all phases of the development and use of drugs and on professional pharmaceutical practice. The scope of the database ranges from the clinical and practical, to the theoretical aspects of toxicology literature. A unique feature of abstracts reporting clinical studies is the inclusion of the study design, number of patients, dosage, dosage forms, and dosage schedule.



Tips [top]

USE FILE 153

to follow toxicity issues as related to the pharmaceutical industry in general.

USE /NA OR NA=

to search for specific chemical names:

     SELECT ACETAMINOPHEN/NA

USE RN=

to search by CAS® Registry Number:

     SELECT RN=103-90-2

USE /SH OR SH=

to search for Section Headings:

     SELECT SH=ENVIRONMENTAL TOXICITY


Subject Coverage [top]

Subjects are focussed on toxicity as it relates to:

  • Adverse Drug Reactions
  • Biopharmaceutics
  • Drug Analysis
  • Drug Evaluations
  • Drug Interactions
  • Drug Metabolism and Body Distribution
  • Drug Stability
  • Environment
  • Investigational Drugs
  • Methodology and Drug Testing
  • Pharmaceutical Chemistry
  • Pharmaceutics
  • Pharmacoeconomics
  • Pharmacognosy
  • Pharmacology


Sources [top]

IPA Toxicology draws material from over 850 primary journals from throughout the world and from all U.S. state pharmacy journals.



Print Counterparts [top]

  • International Pharmaceutical Abstracts


Dialog File Data [top]

Dates Covered: 1970 to the present
File Size: 288.110 records as of July 2004
Update Frequency: Biweekly (Approximately 500 records per update)


Document Types Indexed [top]

  • Journal Articles


Geographic Coverage [top]

  • International


Geographic Restrictions [top]

  • None


Special Features [top]


DialIndex/OneSearch Categories [top]

ACRONYM CATEGORY NAME
TOXSEARC Toxfile, IPA, Biosis toxicology


Contact [top]

IPA Toxicology is produced by Thomson Scientific. Questions concerning file content should be directed to:

Thomson Scientific
3501 Market Street
Philadelphia, PA 19104

Telephone: +1 301-424-3325
E-Mail: yinghua.wang@thomson.com


Terms and Conditions [top]

For Dialog's Redistribution and Archive Policy, enter HELP ERA online. The following terms and conditions also apply.

IPA Toxicology (File 153)

This data is copyrighted by The Thomson Corp. The Thomson Corp. represents that the database provided hereunder was formulated with a reasonable standard of care, and in conformance to professional standards in the field. Except with respect to the foregoing and as otherwise specifically provided in this agreement, The Thomson Corp. makes no representations or warranties, express or implied, including but not limited to, any implied warranty of merchantability or fitness for a particular purpose, with respect to such database and specifically disclaims all such warranties and representations.


Dialog Standard Terms & Conditions apply.


SAMPLE RECORD [top]

    DIALOG(R)File 153:IPA Toxicology 
    (c) 2004 The Thomson Corp. All rts. reserv. 
     
  AA=  0000313328  41-08505 
  /TI  Comparative  pharmacokinetics  of acetyl salicylic acid and its metabolites 
    in children suffering from autoimmune diseases 
  AU=  Olguin, HJ; Perez, JF; Asseff, IL; Abdala, AL; Rodriguez, LC 
  CS=  INP, Farmacol Lab, Avenida Iman 1,3er Piso Colonia, Mexico City, DF, Mexico 
      juarezol@yahoo.com 
  JN=,SO=,PY=  Biopharmaceutics and Drug Disposition (England), V25, (1), p1-7, 2004 
  CD=,SN=,LA=  CODEN: BDDID8  ISSN: 0142-2782  LANGUAGE: English 
  RT=  RECORD TYPE: Abstract 
     
  /AB       To compare the effect produced by juvenile rheumatoid arthritis (JRA) 
    or rheumatic fever (RF) on the pharmacokinetics of acetyl salicylic acid 
    (ASA) and its metabolites in children with autoirnmune diseases (AD), a 
    prospective, open labelled study was performed in 17 children with JRA and 
    17 with RF who received a single dose of 25 mg ASA/ kg orally. The 
    pharmacokinetics of ASA and its metabolites were determined. The blood and 
    urine levels of each salicylate collected during 24h were measured by HPLC. 
    A group of 15 healthy teenage volunteers was included as a control group. 
         The maximum plasma concentration, half-life time, area under the curve 
    and the amount of salicylates excreted were statistically different between 
    the JRA and the RF groups, as well as between the RF group and the 
    controls, however, there were no significant differences between the JRA 
    group and the controls. It was concluded that dosage schemes must be 
    adjusted for JRA patients, since the half life in these patients is longer 
    than in RF patients. However, due to ample variability of pharmacokinetic 
    parameters it is recommended that dose schemes are individualized on the 
    type of autoimmune disease considered. (22 references) 
     
  RN=,/NA,NA=  CAS REGISTRY NUMBERS: 50-78-2 (Aspirin) 
  /TN,TN=,/NA,NA=  CHEMICAL/BRAND NAMES: Acetylsalicylic acid 
  /DE  DESCRIPTORS: Pediatrics--aspirin; Pharmacokinetics--aspirin; Autoimmune 
     diseases--aspirin; Arthritis--aspirin; Rheumatic fever--aspirin; 
      Metabolism--aspirin; Blood levels--aspirin; Urine levels--aspirin; Half 
      life--aspirin; Excretion--aspirin; Dosage schedules--aspirin; Anti 
      inflammatory agents--aspirin 
  /SH,SH=,/PR  SECTION HEADINGS: Drug metabolism & body distribution (15); Drug 
      evaluations (06) 
  AH=,/TC,TC=  THERAPEUTIC CLASS: 28.08.04 (Anti inflammatory agents--Aspirin) 


BASIC INDEX [top]

SEARCH
SUFFIX
DISPLAY
CODE
FIELD NAME
INDEXING
SELECT EXAMPLES
None None All Basic Index Fields Word S RHEUMATOID(W)ARTHRITIS?
/AB AB Abstract1 Word S RHEUMATIC(W)FEVER/AB
/DE DE Descriptor2 Word
& Phrase
S URINE(W)LEVEL?/DE
S DOSAGE SCHEDULE?/DE
/NA NA Chemical Name3,4 Word
& Phrase
S ACETYLSALICYLIC(W)ACID/NA
S ACETYLSALICYLIC ACID/NA
/PR PR Primary Section Heading4 Word S DRUG(W)METABOLISM?/PR
/SH SH Section Heading Name4 Word S DRUG(W)EVALUATION?/SH
/TC TC Therapeutic Class Name and Drug Term Word S ANTI(W)INFLAMMATORY(W)AGENT?/TC
/TI TI Title Word S AUTOIMMUNE(W)DISEASE?/TI
/TN TN Brand Name4 Word
& Phrase
S BRICANYL/TN
S ACETYLSALICYLIC ACID/TN

1 Abstracts present for 90% of records.

2 Also /DF.

3 Includes brand, chemical, and drug names and laboratory codes.

4 Searchable in the Basic Index and in the Additional Indexes.


ADDITIONAL INDEXES [top]

SEARCH
PREFIX
DISPLAY
CODE
FIELD NAME
INDEXING
SELECT EXAMPLES
AA= AA IPA Accession Number Phrase S AA=41-08505
AU= AU Author Phrase S AU=OLGUIN, H?
None AZ DIALOG Accession Number
CD= CD CODEN Phrase S CD=BDDID8
CS= CS Corporate Source Word S CS=(INP(W)FARMACOL(W)LAB)
JN= JN Journal Name Phrase S JN=BIOPHARMACEUTIC?
LA= LA Language Phrase S LA=ENGLISH
NA= NA Chemical Name3,4 Phrase S NA=ACETYLSALICYCLIC ACID?
None NT Note
PY= PY Publication Year Phrase S PY=2004
None RF References
RN= RN CAS(R) Registry Number Phrase S RN=50-78-2
RT= RT Record Type Phrase S RT=ABSTRACT
SH= PR Primary Section Heading4 Phrase S SH=DRUG METABOLISM?/PR
S SH=15/PR
SH= SH Section Heading Code and Name4 Phrase S SH=06
S SH=DRUG EVALUATION?
SN= SN International Standard Serial Number (ISSN) Phrase S SN=0142-2782
SO= SO Source Information6 Word S SO=(DRUG(W)DISPOSITION(S)ENGLAND)
TC= TC Therapeutic Class Code5 Phrase S TC=28
S TC=28.08
S TC=28.08.04
TN= TN Brand Name4 Phrase S TN=ACETYLSALICYLIC ACID?
UD= None Update Phrase S UD=9999

5 Also searchable using AH=.

6 Display includes journal name, volume, issue, pagination, and publication year.


LIMIT [top]

SUFFIX FIELD NAME EXAMPLES
/ABS Record has an Abstract S S2/ABS
/ENG English-Language Articles S S2/ENG
/HUMAN Human Subject S S1/HUMAN
/NOABS Record does not have an Abstract S S4/NOABS
/NONENG Non-English-Language Articles S S4/NONENG
/YYYY Publication Year S S2/2002:2003


SORT [top]

SORTABLE FIELDS EXAMPLES
AU, JN, PY, TI SORT S1/ALL/PY/D
SORT S3/ALL/AU


RANK [top]

RANK FIELDS EXAMPLES
All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. RANK AU S3


MAP [top]

MAP FIELDS EXAMPLES
NA, RN MAP RN TEMP S2


USER-DEFINED FORMAT OPTIONS [top]

User-defined formats may be specified using the display codes indicated in the Search Options tables. TYPE S3/TI,NA,PY/1-5
PRINT S2/TI,AB/ALL


PREDEFINED FORMAT OPTIONS [top]

NO.
DIALOGWEB
FORMAT
RECORD CONTENT
1 -- DIALOG Accession Number
2 -- Bibliographic Citation and Indexing
3 Medium Bibliographic Citation
4 -- Full Record with Tagged Fields
5 -- Full Record
6 Short Title and Publication Year
7 Long Bibliographic Citation and Abstract
8 Free Title, Indexing, and Publication Year
9 Full Full Record
K -- KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats


DIRECT RECORD ACCESS [top]

FIELD NAME EXAMPLES
DIALOG Accession Number TYPE 00234446/5
DISPLAY 00744483/9
PRINT 00224557/5


Rates [top]

Rates For File: IPA Toxicology[153]
Cost per DialUnit:                 $8.75
Cost per minute:                   $1.62
ALERT (default)                    $5.25
ALERT (Monthly)                    $9.50
ALERT (Biweekly/twice a month)     $5.25
ALERT (Weekly)                 *   $5.25
ALERT (Daily)                  *   $5.25
ALERT (Calendar weekly)        *   $5.25
ALERT (Intraday)               *   $5.25
* = custom scheduled Alerts only
ALERT Number of included prints        0

Format    Types   Prints
     1    $0.00    $0.00
     2    $3.50    $3.50
     3    $3.50    $3.50
     4    $3.50    $3.50
     5    $3.50    $3.50
     6    $0.00    $0.00
     7    $3.50    $3.50
     8    $0.00    $0.00
     9    $3.50    $3.50
KWIC95    $0.33       NA
KWIC96    $0.33       NA

REDIST/COPY Multiplier Table:

      Range      Multiplier
        1-2       1.00
       3-25       1.50
     26-100       3.00
    101-200       4.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00

ARCHIVE Multiplier Table:

      Range      Multiplier
       1-25       1.50
     26-200       3.00
    201-500       6.00
   501-1000       8.00
 1001 or more    10.00
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