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Last Loaded on Web: Monday, April 01, 2013
IPA Toxicology is a subset of the International Pharmaceutical Abstracts database (File 74) providing focused toxicology information on all phases of the development and use of drugs and on professional pharmaceutical practice. The scope of the database ranges from the clinical and practical, to the theoretical aspects of toxicology literature. A unique feature of abstracts reporting clinical studies is the inclusion of the study design, number of patients, dosage, dosage forms, and dosage schedule.
USE FILE 153to follow toxicity issues as related to the pharmaceutical industry in general. USE /NA OR NA=to search for specific chemical names: SELECT ACETAMINOPHEN/NAUSE RN=to search by CAS® Registry Number: SELECT RN=103-90-2USE /SH OR SH=to search for Section Headings: SELECT SH=ENVIRONMENTAL TOXICITY |
Subjects are focussed on toxicity as it relates to:
IPA Toxicology draws material from over 850 primary journals from throughout the world and from all U.S. state pharmacy journals.
| Dates Covered: | 1970 to the present |
|---|---|
| File Size: | 288.110 records as of July 2004 |
| Update Frequency: | Biweekly (Approximately 500 records per update) |
| ACRONYM | CATEGORY NAME |
|---|---|
| TOXSEARC | Toxfile, IPA, Biosis toxicology |
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IPA Toxicology is produced by Thomson Scientific. Questions concerning file content should be directed to: 3501 Market Street Philadelphia, PA 19104
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For Dialog's Redistribution and Archive Policy, enter HELP ERA online. The following terms and conditions also apply.
IPA Toxicology (File 153)
This data is copyrighted by The Thomson Corp. The Thomson Corp. represents that the database provided hereunder was formulated with a reasonable standard of care, and in conformance to professional standards in the field. Except with respect to the foregoing and as otherwise specifically provided in this agreement, The Thomson Corp. makes no representations or warranties, express or implied, including but not limited to, any implied warranty of merchantability or fitness for a particular purpose, with respect to such database and specifically disclaims all such warranties and representations.
| DIALOG(R)File 153:IPA Toxicology | |
| (c) 2004 The Thomson Corp. All rts. reserv. | |
| AA= | 0000313328 41-08505 |
| /TI | Comparative pharmacokinetics of acetyl salicylic acid and its metabolites |
| in children suffering from autoimmune diseases | |
| AU= | Olguin, HJ; Perez, JF; Asseff, IL; Abdala, AL; Rodriguez, LC |
| CS= | INP, Farmacol Lab, Avenida Iman 1,3er Piso Colonia, Mexico City, DF, Mexico |
| juarezol@yahoo.com | |
| JN=,SO=,PY= | Biopharmaceutics and Drug Disposition (England), V25, (1), p1-7, 2004 |
| CD=,SN=,LA= | CODEN: BDDID8 ISSN: 0142-2782 LANGUAGE: English |
| RT= | RECORD TYPE: Abstract |
| /AB | To compare the effect produced by juvenile rheumatoid arthritis (JRA) |
| or rheumatic fever (RF) on the pharmacokinetics of acetyl salicylic acid | |
| (ASA) and its metabolites in children with autoirnmune diseases (AD), a | |
| prospective, open labelled study was performed in 17 children with JRA and | |
| 17 with RF who received a single dose of 25 mg ASA/ kg orally. The | |
| pharmacokinetics of ASA and its metabolites were determined. The blood and | |
| urine levels of each salicylate collected during 24h were measured by HPLC. | |
| A group of 15 healthy teenage volunteers was included as a control group. | |
| The maximum plasma concentration, half-life time, area under the curve | |
| and the amount of salicylates excreted were statistically different between | |
| the JRA and the RF groups, as well as between the RF group and the | |
| controls, however, there were no significant differences between the JRA | |
| group and the controls. It was concluded that dosage schemes must be | |
| adjusted for JRA patients, since the half life in these patients is longer | |
| than in RF patients. However, due to ample variability of pharmacokinetic | |
| parameters it is recommended that dose schemes are individualized on the | |
| type of autoimmune disease considered. (22 references) | |
| RN=,/NA,NA= | CAS REGISTRY NUMBERS: 50-78-2 (Aspirin) |
| /TN,TN=,/NA,NA= | CHEMICAL/BRAND NAMES: Acetylsalicylic acid |
| /DE | DESCRIPTORS: Pediatrics--aspirin; Pharmacokinetics--aspirin; Autoimmune |
| diseases--aspirin; Arthritis--aspirin; Rheumatic fever--aspirin; | |
| Metabolism--aspirin; Blood levels--aspirin; Urine levels--aspirin; Half | |
| life--aspirin; Excretion--aspirin; Dosage schedules--aspirin; Anti | |
| inflammatory agents--aspirin | |
| /SH,SH=,/PR | SECTION HEADINGS: Drug metabolism & body distribution (15); Drug |
| evaluations (06) | |
| AH=,/TC,TC= | THERAPEUTIC CLASS: 28.08.04 (Anti inflammatory agents--Aspirin) |
| SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| None | None | All Basic Index Fields | Word | S RHEUMATOID(W)ARTHRITIS? |
| /AB | AB | Abstract1 | Word | S RHEUMATIC(W)FEVER/AB |
| /DE | DE | Descriptor2 | Word & Phrase |
S URINE(W)LEVEL?/DE S DOSAGE SCHEDULE?/DE |
| /NA | NA | Chemical Name3,4 | Word & Phrase |
S ACETYLSALICYLIC(W)ACID/NA S ACETYLSALICYLIC ACID/NA |
| /PR | PR | Primary Section Heading4 | Word | S DRUG(W)METABOLISM?/PR |
| /SH | SH | Section Heading Name4 | Word | S DRUG(W)EVALUATION?/SH |
| /TC | TC | Therapeutic Class Name and Drug Term | Word | S ANTI(W)INFLAMMATORY(W)AGENT?/TC |
| /TI | TI | Title | Word | S AUTOIMMUNE(W)DISEASE?/TI |
| /TN | TN | Brand Name4 | Word & Phrase |
S BRICANYL/TN S ACETYLSALICYLIC ACID/TN |
1 Abstracts present for 90% of records.
3 Includes brand, chemical, and drug names and laboratory codes.
4 Searchable in the Basic Index and in the Additional Indexes.
| SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
|---|---|---|---|---|
| AA= | AA | IPA Accession Number | Phrase | S AA=41-08505 |
| AU= | AU | Author | Phrase | S AU=OLGUIN, H? |
| None | AZ | DIALOG Accession Number | ||
| CD= | CD | CODEN | Phrase | S CD=BDDID8 |
| CS= | CS | Corporate Source | Word | S CS=(INP(W)FARMACOL(W)LAB) |
| JN= | JN | Journal Name | Phrase | S JN=BIOPHARMACEUTIC? |
| LA= | LA | Language | Phrase | S LA=ENGLISH |
| NA= | NA | Chemical Name3,4 | Phrase | S NA=ACETYLSALICYCLIC ACID? |
| None | NT | Note | ||
| PY= | PY | Publication Year | Phrase | S PY=2004 |
| None | RF | References | ||
| RN= | RN | CAS(R) Registry Number | Phrase | S RN=50-78-2 |
| RT= | RT | Record Type | Phrase | S RT=ABSTRACT |
| SH= | PR | Primary Section Heading4 | Phrase | S SH=DRUG METABOLISM?/PR S SH=15/PR |
| SH= | SH | Section Heading Code and Name4 | Phrase | S SH=06 S SH=DRUG EVALUATION? |
| SN= | SN | International Standard Serial Number (ISSN) | Phrase | S SN=0142-2782 |
| SO= | SO | Source Information6 | Word | S SO=(DRUG(W)DISPOSITION(S)ENGLAND) |
| TC= | TC | Therapeutic Class Code5 | Phrase | S TC=28 S TC=28.08 S TC=28.08.04 |
| TN= | TN | Brand Name4 | Phrase | S TN=ACETYLSALICYLIC ACID? |
| UD= | None | Update | Phrase | S UD=9999 |
6 Display includes journal name, volume, issue, pagination, and publication year.
| SUFFIX | FIELD NAME | EXAMPLES |
|---|---|---|
| /ABS | Record has an Abstract | S S2/ABS |
| /ENG | English-Language Articles | S S2/ENG |
| /HUMAN | Human Subject | S S1/HUMAN |
| /NOABS | Record does not have an Abstract | S S4/NOABS |
| /NONENG | Non-English-Language Articles | S S4/NONENG |
| /YYYY | Publication Year | S S2/2002:2003 |
| SORTABLE FIELDS | EXAMPLES |
|---|---|
| AU, JN, PY, TI | SORT S1/ALL/PY/D SORT S3/ALL/AU |
| RANK FIELDS | EXAMPLES |
|---|---|
| All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. | RANK AU S3 |
| MAP FIELDS | EXAMPLES |
|---|---|
| NA, RN | MAP RN TEMP S2 |
| User-defined formats may be specified using the display codes indicated in the Search Options tables. | TYPE S3/TI,NA,PY/1-5 PRINT S2/TI,AB/ALL |
| NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
|---|---|---|
| 1 | -- | DIALOG Accession Number |
| 2 | -- | Bibliographic Citation and Indexing |
| 3 | Medium | Bibliographic Citation |
| 4 | -- | Full Record with Tagged Fields |
| 5 | -- | Full Record |
| 6 | Short | Title and Publication Year |
| 7 | Long | Bibliographic Citation and Abstract |
| 8 | Free | Title, Indexing, and Publication Year |
| 9 | Full | Full Record |
| K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
| FIELD NAME | EXAMPLES | ||
|---|---|---|---|
| DIALOG Accession Number | TYPE 00234446/5 DISPLAY 00744483/9 PRINT 00224557/5 |
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Rates For File: IPA Toxicology[153]
Cost per DialUnit: $8.75
Cost per minute: $1.62
ALERT (default) $5.25
ALERT (Monthly) $9.50
ALERT (Biweekly/twice a month) $5.25
ALERT (Weekly) * $5.25
ALERT (Daily) * $5.25
ALERT (Calendar weekly) * $5.25
ALERT (Intraday) * $5.25
* = custom scheduled Alerts only
ALERT Number of included prints 0
Format Types Prints
1 $0.00 $0.00
2 $3.50 $3.50
3 $3.50 $3.50
4 $3.50 $3.50
5 $3.50 $3.50
6 $0.00 $0.00
7 $3.50 $3.50
8 $0.00 $0.00
9 $3.50 $3.50
KWIC95 $0.33 NA
KWIC96 $0.33 NA
REDIST/COPY Multiplier Table:
Range Multiplier
1-2 1.00
3-25 1.50
26-100 3.00
101-200 4.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
ARCHIVE Multiplier Table:
Range Multiplier
1-25 1.50
26-200 3.00
201-500 6.00
501-1000 8.00
1001 or more 10.00
